Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5VV0

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(4-Methylpyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0006809biological_processnitric oxide biosynthetic process
B0004517molecular_functionnitric-oxide synthase activity
B0006809biological_processnitric oxide biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue HEM A 801
ChainResidue
ATRP414
ATYR711
AH4B802
A9OM803
AHOH905
AHOH925
AHOH926
AHOH1013
AARG419
ACYS420
APHE589
ASER590
ATRP592
AGLU597
ATRP683
APHE709

site_idAC2
Number of Residues15
Detailsbinding site for residue H4B A 802
ChainResidue
ASER339
AARG601
AVAL682
ATRP683
AHEM801
AHOH925
AHOH956
AHOH1009
AHOH1018
AHOH1115
BTRP681
BPHE696
BHIS697
BGLN698
BGLU699

site_idAC3
Number of Residues6
Detailsbinding site for residue 9OM A 803
ChainResidue
AMET341
AVAL572
ATRP592
AGLU597
AHEM801
AHOH905

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 804
ChainResidue
ACYS331
ACYS336
BCYS331
BCYS336

site_idAC5
Number of Residues16
Detailsbinding site for residue HEM B 801
ChainResidue
BTRP414
BARG419
BCYS420
BSER462
BPHE589
BSER590
BTRP592
BGLU597
BPHE709
BTYR711
BH4B802
B9OM803
BHOH920
BHOH922
BHOH927
BHOH930

site_idAC6
Number of Residues15
Detailsbinding site for residue H4B B 802
ChainResidue
ATRP681
APHE696
AHIS697
AGLN698
AGLU699
BSER339
BARG601
BVAL682
BTRP683
BHEM801
BHOH922
BHOH977
BHOH1000
BHOH1003
BHOH1043

site_idAC7
Number of Residues9
Detailsbinding site for residue 9OM B 803
ChainResidue
ATRP311
BMET341
BVAL572
BTRP592
BGLU597
BTRP683
BHEM801
BHOH927
BHOH1077

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCVGRIqW
ChainResidueDetails
AARG419-TRP426

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
ChainResidueDetails
ASER339
BSER339
BGLN483
BTRP592
BTYR593
BGLU597
BVAL682
BTRP683
BPHE696
BTYR711
AGLN483
ATRP592
ATYR593
AGLU597
AVAL682
ATRP683
APHE696
ATYR711

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
ChainResidueDetails
ACYS420
BCYS420

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon