5VOK

Crystal structure of the C7orf59-HBXIP dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0008361	biological_process	regulation of cell size
A	0009615	biological_process	response to virus
A	0010628	biological_process	positive regulation of gene expression
A	0019079	biological_process	viral genome replication
A	0031902	cellular_component	late endosome membrane
A	0032008	biological_process	positive regulation of TOR signaling
A	0032757	biological_process	positive regulation of interleukin-8 production
A	0032991	cellular_component	protein-containing complex
A	0038202	biological_process	TORC1 signaling
A	0043066	biological_process	negative regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060090	molecular_function	molecular adaptor activity
A	0061462	biological_process	protein localization to lysosome
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071986	cellular_component	Ragulator complex
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
A	1990877	cellular_component	FNIP-folliculin RagC/D GAP
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0008361	biological_process	regulation of cell size
B	0031902	cellular_component	late endosome membrane
B	0032008	biological_process	positive regulation of TOR signaling
B	0038202	biological_process	TORC1 signaling
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0060090	molecular_function	molecular adaptor activity
B	0061462	biological_process	protein localization to lysosome
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071986	cellular_component	Ragulator complex
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1990877	cellular_component	FNIP-folliculin RagC/D GAP
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0008361	biological_process	regulation of cell size
C	0009615	biological_process	response to virus
C	0010628	biological_process	positive regulation of gene expression
C	0019079	biological_process	viral genome replication
C	0031902	cellular_component	late endosome membrane
C	0032008	biological_process	positive regulation of TOR signaling
C	0032757	biological_process	positive regulation of interleukin-8 production
C	0032991	cellular_component	protein-containing complex
C	0038202	biological_process	TORC1 signaling
C	0043066	biological_process	negative regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0060090	molecular_function	molecular adaptor activity
C	0061462	biological_process	protein localization to lysosome
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071986	cellular_component	Ragulator complex
C	1900182	biological_process	positive regulation of protein localization to nucleus
C	1904263	biological_process	positive regulation of TORC1 signaling
C	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
C	1990877	cellular_component	FNIP-folliculin RagC/D GAP
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0008361	biological_process	regulation of cell size
D	0031902	cellular_component	late endosome membrane
D	0032008	biological_process	positive regulation of TOR signaling
D	0038202	biological_process	TORC1 signaling
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0060090	molecular_function	molecular adaptor activity
D	0061462	biological_process	protein localization to lysosome
D	0071230	biological_process	cellular response to amino acid stimulus
D	0071986	cellular_component	Ragulator complex
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990877	cellular_component	FNIP-folliculin RagC/D GAP
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0008361	biological_process	regulation of cell size
E	0009615	biological_process	response to virus
E	0010628	biological_process	positive regulation of gene expression
E	0019079	biological_process	viral genome replication
E	0031902	cellular_component	late endosome membrane
E	0032008	biological_process	positive regulation of TOR signaling
E	0032757	biological_process	positive regulation of interleukin-8 production
E	0032991	cellular_component	protein-containing complex
E	0038202	biological_process	TORC1 signaling
E	0043066	biological_process	negative regulation of apoptotic process
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0060090	molecular_function	molecular adaptor activity
E	0061462	biological_process	protein localization to lysosome
E	0071230	biological_process	cellular response to amino acid stimulus
E	0071986	cellular_component	Ragulator complex
E	1900182	biological_process	positive regulation of protein localization to nucleus
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
E	1990877	cellular_component	FNIP-folliculin RagC/D GAP
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0008361	biological_process	regulation of cell size
F	0031902	cellular_component	late endosome membrane
F	0032008	biological_process	positive regulation of TOR signaling
F	0038202	biological_process	TORC1 signaling
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0060090	molecular_function	molecular adaptor activity
F	0061462	biological_process	protein localization to lysosome
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071986	cellular_component	Ragulator complex
F	1904263	biological_process	positive regulation of TORC1 signaling
F	1990877	cellular_component	FNIP-folliculin RagC/D GAP
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0008361	biological_process	regulation of cell size
G	0009615	biological_process	response to virus
G	0010628	biological_process	positive regulation of gene expression
G	0019079	biological_process	viral genome replication
G	0031902	cellular_component	late endosome membrane
G	0032008	biological_process	positive regulation of TOR signaling
G	0032757	biological_process	positive regulation of interleukin-8 production
G	0032991	cellular_component	protein-containing complex
G	0038202	biological_process	TORC1 signaling
G	0043066	biological_process	negative regulation of apoptotic process
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0060090	molecular_function	molecular adaptor activity
G	0061462	biological_process	protein localization to lysosome
G	0071230	biological_process	cellular response to amino acid stimulus
G	0071986	cellular_component	Ragulator complex
G	1900182	biological_process	positive regulation of protein localization to nucleus
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
G	1990877	cellular_component	FNIP-folliculin RagC/D GAP
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005764	cellular_component	lysosome
H	0005765	cellular_component	lysosomal membrane
H	0008361	biological_process	regulation of cell size
H	0031902	cellular_component	late endosome membrane
H	0032008	biological_process	positive regulation of TOR signaling
H	0038202	biological_process	TORC1 signaling
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0060090	molecular_function	molecular adaptor activity
H	0061462	biological_process	protein localization to lysosome
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
H	1904263	biological_process	positive regulation of TORC1 signaling
H	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1
D	MET1
F	MET1
H	MET1

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
B	THR2
D	THR2
F	THR2
H	THR2

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31314152

Chain	Residue	Details
B	SER67
D	SER67
F	SER67
H	SER67

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