5VNB

YEATS in complex with histone H3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006355	biological_process	regulation of DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue EDO A 201

Chain	Residue
A	ASN126

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site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 202

Chain	Residue
A	GLU87
C	GLU137

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site_id	AC3
Number of Residues	3
Details	binding site for residue EDO B 201

Chain	Residue
B	EDO203
B	EDO205
B	EDO206

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site_id	AC4
Number of Residues	2
Details	binding site for residue EDO B 203

Chain	Residue
B	ALA127
B	EDO201

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site_id	AC5
Number of Residues	2
Details	binding site for residue EDO B 204

Chain	Residue
B	EDO206
B	ASP124

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site_id	AC6
Number of Residues	3
Details	binding site for residue EDO B 205

Chain	Residue
B	GLN122
B	EDO201
B	EDO206

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site_id	AC7
Number of Residues	5
Details	binding site for residue EDO B 206

Chain	Residue
B	ASP124
B	ALA127
B	EDO201
B	EDO204
B	EDO205

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 B 207

Chain	Residue
B	GLU87
D	GLU137

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 208

Chain	Residue
B	TYR50
B	LYS52
B	GLU87

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 B 209

Chain	Residue
A	LYS131
A	HOH303
B	LYS131
B	LYS132
B	THR133

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 C 201

Chain	Residue
B	ASN126
B	LYS131
C	LYS52
C	HOH320

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site_id	AD3
Number of Residues	13
Details	binding site for Ligand residues ALY K 23 through ALA K 24 bound to THR K 22

Chain	Residue
B	HIS71
B	SER73
B	TYR74
B	GLY92
B	TRP93
B	GLY94
B	GLU95
B	PHE96
B	HOH314
D	GLU97
K	THR22
K	ALA25
K	ARG26

---

site_id	AD4
Number of Residues	12
Details	binding site for Di-peptide ARG K 26 and ALY K 27

Chain	Residue
A	ASN108
A	GLN145
B	GLU97
D	HIS71
D	TYR74
D	GLY92
D	TRP93
D	GLY94
D	GLU95
K	ALA24
K	ALA25
K	SER28

---

site_id	AD5
Number of Residues	10
Details	binding site for Di-peptide ALY K 27 and SER K 28

Chain	Residue
A	ASN108
A	GLN145
D	HIS71
D	TYR74
D	GLY92
D	TRP93
D	GLY94
D	GLU95
K	ARG26
K	ALA29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Diacetylated histone H3 binding","evidences":[{"source":"PubMed","id":"29900004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30071723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VNB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Interacts with diacetylated histone H3","evidences":[{"source":"PubMed","id":"29900004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30071723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VNB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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