Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5VN0

Water-forming NADH oxidase from Lactobacillus brevis (LbNOX) bound to NADH.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0016491	molecular_function	oxidoreductase activity
D	0000166	molecular_function	nucleotide binding
D	0016491	molecular_function	oxidoreductase activity
E	0000166	molecular_function	nucleotide binding
E	0016491	molecular_function	oxidoreductase activity
F	0000166	molecular_function	nucleotide binding
F	0016491	molecular_function	oxidoreductase activity
G	0000166	molecular_function	nucleotide binding
G	0016491	molecular_function	oxidoreductase activity
H	0000166	molecular_function	nucleotide binding
H	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	39
Details	binding site for residue FAD A 501

Chain	Residue
A	GLY7
A	HIS77
A	ASN78
A	VAL79
A	THR110
A	SER111
A	GLY112
A	SER113
A	CYS131
A	LYS132
A	ILE158
A	THR9
A	PHE242
A	ASN245
A	LEU248
A	GLY278
A	ASP279
A	LEU296
A	ALA297
A	THR298
A	OXY502
A	NAI503
A	HIS10
A	HOH649
A	HOH653
A	HOH669
A	HOH693
A	HOH761
A	HOH845
A	HOH859
B	PHE422
B	GLN423
B	HOH733
A	ALA11
A	GLU32
A	ARG33
A	ASN34
A	SER41
A	CYS42

site_id	AC2
Number of Residues	4
Details	binding site for residue OXY A 502

Chain	Residue
A	SER41
A	CYS42
A	FAD501
A	HOH649

site_id	AC3
Number of Residues	27
Details	binding site for residue NAI A 503

Chain	Residue
A	GLY156
A	TYR157
A	ILE158
A	GLU161
A	ASP177
A	ALA178
A	MET179
A	PRO184
A	LYS185
A	TYR186
A	CYS239
A	ILE240
A	GLY241
A	PHE242
A	PRO295
A	LEU296
A	GLY326
A	FAD501
A	HOH633
A	HOH645
A	HOH697
A	HOH721
A	HOH825
A	HOH841
A	HOH863
A	HOH869
B	GLN423

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 504

Chain	Residue
A	ARG332
A	MET390

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 505

Chain	Residue
A	PHE14
A	TYR60
A	HOH715
A	HOH798
A	HOH867

site_id	AC6
Number of Residues	38
Details	binding site for residue FAD B 501

Chain	Residue
B	ASN245
B	LEU248
B	GLY278
B	ASP279
B	LEU296
B	ALA297
B	OXY502
B	NAI503
B	HOH631
B	HOH642
B	HOH666
B	HOH673
B	HOH689
B	HOH719
B	HOH741
B	HOH809
A	PHE422
A	GLN423
B	GLY7
B	THR9
B	HIS10
B	ALA11
B	GLU32
B	ARG33
B	ASN34
B	SER41
B	CYS42
B	HIS77
B	ASN78
B	VAL79
B	THR110
B	SER111
B	GLY112
B	SER113
B	CYS131
B	LYS132
B	ILE158
B	PHE242

site_id	AC7
Number of Residues	4
Details	binding site for residue OXY B 502

Chain	Residue
B	SER41
B	CYS42
B	FAD501
B	HOH631

site_id	AC8
Number of Residues	25
Details	binding site for residue NAI B 503

Chain	Residue
A	GLN423
B	GLY156
B	TYR157
B	ILE158
B	GLU161
B	ASP177
B	ALA178
B	MET179
B	PRO184
B	LYS185
B	TYR186
B	CYS239
B	ILE240
B	GLY241
B	PHE242
B	PRO295
B	LEU296
B	GLY326
B	FAD501
B	HOH636
B	HOH653
B	HOH671
B	HOH693
B	HOH698
B	HOH827

site_id	AC9
Number of Residues	7
Details	binding site for residue EDO B 504

Chain	Residue
A	PRO429
A	HOH796
B	PHE14
B	HOH668
B	HOH672
B	HOH789
B	HOH813

site_id	AD1
Number of Residues	40
Details	binding site for residue FAD C 501

Chain	Residue
C	GLY7
C	THR9
C	HIS10
C	ALA11
C	GLU32
C	ARG33
C	ASN34
C	SER41
C	CYS42
C	HIS77
C	ASN78
C	VAL79
C	THR110
C	SER111
C	GLY112
C	SER113
C	CYS131
C	LYS132
C	ILE158
C	PHE242
C	ASN245
C	LEU248
C	GLY278
C	ASP279
C	LEU296
C	ALA297
C	ALA300
C	OXY502
C	NAI503
C	HOH601
C	HOH611
C	HOH654
C	HOH667
C	HOH676
C	HOH684
C	HOH707
C	HOH769
C	HOH806
D	PHE422
D	GLN423

site_id	AD2
Number of Residues	4
Details	binding site for residue OXY C 502

Chain	Residue
C	SER41
C	CYS42
C	FAD501
C	HOH676

site_id	AD3
Number of Residues	26
Details	binding site for residue NAI C 503

Chain	Residue
C	GLY156
C	TYR157
C	ILE158
C	GLU161
C	ASP177
C	ALA178
C	MET179
C	PRO184
C	LYS185
C	TYR186
C	CYS239
C	ILE240
C	GLY241
C	PHE242
C	PRO295
C	LEU296
C	GLY326
C	FAD501
C	HOH630
C	HOH640
C	HOH675
C	HOH693
C	HOH743
C	HOH811
C	HOH831
D	GLN423

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO C 504

Chain	Residue
C	ARG332
C	GLU357
C	MET390

site_id	AD5
Number of Residues	38
Details	binding site for residue FAD D 501

Chain	Residue
C	PHE422
C	GLN423
C	HOH729
D	GLY7
D	THR9
D	HIS10
D	ALA11
D	GLU32
D	ARG33
D	ASN34
D	SER41
D	CYS42
D	HIS77
D	ASN78
D	VAL79
D	THR110
D	SER111
D	GLY112
D	SER113
D	CYS131
D	LYS132
D	ILE158
D	PHE242
D	ASN245
D	LEU248
D	GLY278
D	ASP279
D	LEU296
D	ALA297
D	THR298
D	OXY502
D	NAI503
D	HOH650
D	HOH700
D	HOH702
D	HOH709
D	HOH730
D	HOH825

site_id	AD6
Number of Residues	5
Details	binding site for residue OXY D 502

Chain	Residue
C	PHE422
D	SER41
D	CYS42
D	FAD501
D	HOH730

site_id	AD7
Number of Residues	27
Details	binding site for residue NAI D 503

Chain	Residue
C	GLN423
D	GLY156
D	TYR157
D	ILE158
D	GLU161
D	ASP177
D	ALA178
D	MET179
D	PRO184
D	LYS185
D	TYR186
D	CYS239
D	ILE240
D	GLY241
D	PHE242
D	PRO295
D	LEU296
D	GLY326
D	FAD501
D	EDO505
D	HOH617
D	HOH671
D	HOH688
D	HOH689
D	HOH755
D	HOH839
D	HOH847

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO D 504

Chain	Residue
D	ARG332
D	GLU357
D	MET390
D	SER391

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO D 505

Chain	Residue
D	LYS185
D	GLY241
D	PHE242
D	NAI503

site_id	AE1
Number of Residues	39
Details	binding site for residue FAD E 501

Chain	Residue
E	GLY7
E	THR9
E	HIS10
E	ALA11
E	GLU32
E	ARG33
E	ASN34
E	SER41
E	CYS42
E	HIS77
E	ASN78
E	VAL79
E	THR110
E	SER111
E	GLY112
E	SER113
E	CYS131
E	LYS132
E	ILE158
E	PHE242
E	ASN245
E	LEU248
E	GLY278
E	ASP279
E	LEU296
E	ALA297
E	ALA300
E	OXY502
E	NAI503
E	HOH627
E	HOH645
E	HOH648
E	HOH672
E	HOH686
E	HOH709
E	HOH724
E	HOH752
F	PHE422
F	GLN423

site_id	AE2
Number of Residues	4
Details	binding site for residue OXY E 502

Chain	Residue
E	SER41
E	CYS42
E	FAD501
E	HOH648

site_id	AE3
Number of Residues	25
Details	binding site for residue NAI E 503

Chain	Residue
E	GLY156
E	TYR157
E	ILE158
E	GLU161
E	ASP177
E	ALA178
E	MET179
E	PRO184
E	LYS185
E	TYR186
E	ILE240
E	GLY241
E	PHE242
E	PRO295
E	LEU296
E	GLY326
E	FAD501
E	HOH652
E	HOH658
E	HOH677
E	HOH679
E	HOH693
E	HOH763
E	HOH805
F	GLN423

site_id	AE4
Number of Residues	8
Details	binding site for residue EDO E 504

Chain	Residue
E	PHE14
E	TYR60
E	HOH640
E	HOH718
E	HOH755
E	HOH776
E	HOH804
F	PRO429

site_id	AE5
Number of Residues	37
Details	binding site for residue FAD F 501

Chain	Residue
E	PHE422
E	GLN423
F	GLY7
F	THR9
F	HIS10
F	ALA11
F	GLU32
F	ARG33
F	ASN34
F	SER41
F	CYS42
F	HIS77
F	ASN78
F	VAL79
F	THR110
F	SER111
F	GLY112
F	SER113
F	CYS131
F	LYS132
F	ILE158
F	PHE242
F	ASN245
F	LEU248
F	GLY278
F	ASP279
F	LEU296
F	ALA297
F	OXY502
F	NAI503
F	HOH621
F	HOH623
F	HOH637
F	HOH669
F	HOH709
F	HOH737
F	HOH741

site_id	AE6
Number of Residues	4
Details	binding site for residue OXY F 502

Chain	Residue
F	SER41
F	CYS42
F	FAD501
F	HOH621

site_id	AE7
Number of Residues	21
Details	binding site for residue NAI F 503

Chain	Residue
E	GLN423
F	GLY156
F	TYR157
F	ILE158
F	GLU161
F	ASP177
F	ALA178
F	MET179
F	LYS185
F	TYR186
F	CYS239
F	ILE240
F	GLY241
F	PHE242
F	PRO295
F	LEU296
F	GLY326
F	FAD501
F	HOH628
F	HOH635
F	HOH638

site_id	AE8
Number of Residues	7
Details	binding site for residue EDO F 504

Chain	Residue
E	PRO429
F	PHE14
F	TYR60
F	HOH655
F	HOH673
F	HOH746
F	HOH748

site_id	AE9
Number of Residues	7
Details	binding site for residue EDO F 505

Chain	Residue
E	VAL316
F	ASP413
F	MET417
F	GLN441
F	HOH663
F	HOH716
F	HOH828

site_id	AF1
Number of Residues	3
Details	binding site for residue EDO F 506

Chain	Residue
F	ARG332
F	GLU357
F	MET390

site_id	AF2
Number of Residues	37
Details	binding site for residue FAD G 501

Chain	Residue
G	GLY7
G	THR9
G	HIS10
G	ALA11
G	GLU32
G	ARG33
G	ASN34
G	SER41
G	CYS42
G	HIS77
G	ASN78
G	VAL79
G	THR110
G	SER111
G	GLY112
G	SER113
G	CYS131
G	LYS132
G	ILE158
G	PHE242
G	ASN245
G	LEU248
G	GLY278
G	ASP279
G	LEU296
G	ALA297
G	OXY502
G	NAI503
G	HOH628
G	HOH632
G	HOH642
G	HOH677
G	HOH683
G	HOH807
H	PHE422
H	GLN423
H	HOH741

site_id	AF3
Number of Residues	4
Details	binding site for residue OXY G 502

Chain	Residue
G	SER41
G	CYS42
G	FAD501
G	HOH642

site_id	AF4
Number of Residues	23
Details	binding site for residue NAI G 503

Chain	Residue
G	GLY156
G	TYR157
G	ILE158
G	GLU161
G	ASP177
G	ALA178
G	MET179
G	LYS185
G	TYR186
G	CYS239
G	ILE240
G	GLY241
G	PHE242
G	PRO295
G	LEU296
G	GLY326
G	FAD501
G	HOH625
G	HOH634
G	HOH651
G	HOH668
G	HOH687
H	GLN423

site_id	AF5
Number of Residues	7
Details	binding site for residue EDO G 504

Chain	Residue
G	PHE14
G	TYR60
G	HOH645
G	HOH746
G	HOH752
G	HOH759
H	PRO429

site_id	AF6
Number of Residues	39
Details	binding site for residue FAD H 501

Chain	Residue
G	PHE422
G	GLN423
H	GLY7
H	THR9
H	HIS10
H	ALA11
H	GLU32
H	ARG33
H	ASN34
H	SER41
H	CYS42
H	HIS77
H	ASN78
H	VAL79
H	THR110
H	SER111
H	GLY112
H	SER113
H	CYS131
H	LYS132
H	ILE158
H	PHE242
H	ASN245
H	LEU248
H	GLY278
H	ASP279
H	LEU296
H	ALA297
H	ALA300
H	OXY502
H	NAI503
H	HOH626
H	HOH673
H	HOH679
H	HOH688
H	HOH706
H	HOH723
H	HOH767
H	HOH781

site_id	AF7
Number of Residues	4
Details	binding site for residue OXY H 502

Chain	Residue
H	SER41
H	CYS42
H	FAD501
H	HOH673

site_id	AF8
Number of Residues	23
Details	binding site for residue NAI H 503

Chain	Residue
G	GLN423
H	GLY156
H	TYR157
H	ILE158
H	GLU161
H	ASP177
H	ALA178
H	MET179
H	PRO184
H	LYS185
H	TYR186
H	ILE240
H	GLY241
H	PHE242
H	PRO295
H	LEU296
H	GLY326
H	FAD501
H	HOH650
H	HOH659
H	HOH693
H	HOH702
H	HOH800

site_id	AF9
Number of Residues	6
Details	binding site for residue EDO H 504

Chain	Residue
G	VAL316
H	ASP413
H	MET417
H	GLN441
H	HOH700
H	HOH842

site_id	AG1
Number of Residues	6
Details	binding site for residue EDO H 505

Chain	Residue
H	ARG332
H	GLU357
H	MET390
H	SER391
H	HOH644
H	HOH802

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)