5VMQ

STRUCTURE OF THE R105A MUTANT CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE AT 2.0-A RESOLUTION

Replaces:  1GQ3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA C 1001

Chain	Residue
B	ASP153
B	HOH408
B	HOH417
C	GLU216
C	ASP253
C	HOH1175

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL C 1002

Chain	Residue
C	HOH1255
C	ARG113
C	ASN132
C	HOH1129

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Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT

Chain	Residue	Details
A	PHE48-THR55

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001

Chain	Residue	Details
A	ARG54
A	PRO268
B	ARG54
B	THR55
B	LYS84
B	ALA105
B	HIS134
B	GLN137
B	ARG167
B	ARG229
B	LEU267
A	THR55
B	PRO268
C	ARG54
C	THR55
C	LYS84
C	ALA105
C	HIS134
C	GLN137
C	ARG167
C	ARG229
C	LEU267
A	LYS84
C	PRO268
A	ALA105
A	HIS134
A	GLN137
A	ARG167
A	ARG229
A	LEU267

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