5VM9

Human Argonaute3 bound to guide RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000794	cellular_component	condensed nuclear chromosome
A	0000932	cellular_component	P-body
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0003727	molecular_function	single-stranded RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006402	biological_process	mRNA catabolic process
A	0006417	biological_process	regulation of translation
A	0010501	biological_process	RNA secondary structure unwinding
A	0010628	biological_process	positive regulation of gene expression
A	0016020	cellular_component	membrane
A	0016442	cellular_component	RISC complex
A	0016787	molecular_function	hydrolase activity
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0031054	biological_process	pre-miRNA processing
A	0035194	biological_process	regulatory ncRNA-mediated post-transcriptional gene silencing
A	0035196	biological_process	miRNA processing
A	0035198	molecular_function	miRNA binding
A	0035278	biological_process	miRNA-mediated gene silencing by inhibition of translation
A	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0046872	molecular_function	metal ion binding
A	0061980	molecular_function	regulatory RNA binding
A	0070578	cellular_component	RISC-loading complex
A	0070922	biological_process	RISC complex assembly
A	0072091	biological_process	regulation of stem cell proliferation
A	0090624	molecular_function	endoribonuclease activity, cleaving miRNA-paired mRNA
A	0090625	biological_process	siRNA-mediated gene silencing by mRNA destabilization
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1990904	cellular_component	ribonucleoprotein complex
C	0000794	cellular_component	condensed nuclear chromosome
C	0000932	cellular_component	P-body
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003725	molecular_function	double-stranded RNA binding
C	0003727	molecular_function	single-stranded RNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004521	molecular_function	RNA endonuclease activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006402	biological_process	mRNA catabolic process
C	0006417	biological_process	regulation of translation
C	0010501	biological_process	RNA secondary structure unwinding
C	0010628	biological_process	positive regulation of gene expression
C	0016020	cellular_component	membrane
C	0016442	cellular_component	RISC complex
C	0016787	molecular_function	hydrolase activity
C	0031047	biological_process	regulatory ncRNA-mediated gene silencing
C	0031054	biological_process	pre-miRNA processing
C	0035194	biological_process	regulatory ncRNA-mediated post-transcriptional gene silencing
C	0035196	biological_process	miRNA processing
C	0035198	molecular_function	miRNA binding
C	0035278	biological_process	miRNA-mediated gene silencing by inhibition of translation
C	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0046872	molecular_function	metal ion binding
C	0061980	molecular_function	regulatory RNA binding
C	0070578	cellular_component	RISC-loading complex
C	0070922	biological_process	RISC complex assembly
C	0072091	biological_process	regulation of stem cell proliferation
C	0090624	molecular_function	endoribonuclease activity, cleaving miRNA-paired mRNA
C	0090625	biological_process	siRNA-mediated gene silencing by mRNA destabilization
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:29040713

Chain	Residue	Details
A	ASP598
A	GLU638
A	ASP670
A	HIS808
C	ASP598
C	GLU638
C	ASP670
C	HIS808

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1
C	MET1

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER825
C	SER825

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