5VKQ
Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001964 | biological_process | startle response |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0007638 | biological_process | mechanosensory behavior |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0010996 | biological_process | response to auditory stimulus |
| A | 0016020 | cellular_component | membrane |
| A | 0030425 | cellular_component | dendrite |
| A | 0030506 | molecular_function | ankyrin binding |
| A | 0034703 | cellular_component | cation channel complex |
| A | 0040011 | biological_process | locomotion |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0050954 | biological_process | sensory perception of mechanical stimulus |
| A | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
| A | 0050975 | biological_process | sensory perception of touch |
| A | 0050976 | biological_process | detection of mechanical stimulus involved in sensory perception of touch |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071260 | biological_process | cellular response to mechanical stimulus |
| B | 0001964 | biological_process | startle response |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005929 | cellular_component | cilium |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0007638 | biological_process | mechanosensory behavior |
| B | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| B | 0010996 | biological_process | response to auditory stimulus |
| B | 0016020 | cellular_component | membrane |
| B | 0030425 | cellular_component | dendrite |
| B | 0030506 | molecular_function | ankyrin binding |
| B | 0034703 | cellular_component | cation channel complex |
| B | 0040011 | biological_process | locomotion |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0050954 | biological_process | sensory perception of mechanical stimulus |
| B | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
| B | 0050975 | biological_process | sensory perception of touch |
| B | 0050976 | biological_process | detection of mechanical stimulus involved in sensory perception of touch |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0071260 | biological_process | cellular response to mechanical stimulus |
| C | 0001964 | biological_process | startle response |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005929 | cellular_component | cilium |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0006816 | biological_process | calcium ion transport |
| C | 0007605 | biological_process | sensory perception of sound |
| C | 0007638 | biological_process | mechanosensory behavior |
| C | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| C | 0010996 | biological_process | response to auditory stimulus |
| C | 0016020 | cellular_component | membrane |
| C | 0030425 | cellular_component | dendrite |
| C | 0030506 | molecular_function | ankyrin binding |
| C | 0034703 | cellular_component | cation channel complex |
| C | 0040011 | biological_process | locomotion |
| C | 0043025 | cellular_component | neuronal cell body |
| C | 0050954 | biological_process | sensory perception of mechanical stimulus |
| C | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
| C | 0050975 | biological_process | sensory perception of touch |
| C | 0050976 | biological_process | detection of mechanical stimulus involved in sensory perception of touch |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0071260 | biological_process | cellular response to mechanical stimulus |
| D | 0001964 | biological_process | startle response |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005929 | cellular_component | cilium |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0006816 | biological_process | calcium ion transport |
| D | 0007605 | biological_process | sensory perception of sound |
| D | 0007638 | biological_process | mechanosensory behavior |
| D | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| D | 0010996 | biological_process | response to auditory stimulus |
| D | 0016020 | cellular_component | membrane |
| D | 0030425 | cellular_component | dendrite |
| D | 0030506 | molecular_function | ankyrin binding |
| D | 0034703 | cellular_component | cation channel complex |
| D | 0040011 | biological_process | locomotion |
| D | 0043025 | cellular_component | neuronal cell body |
| D | 0050954 | biological_process | sensory perception of mechanical stimulus |
| D | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
| D | 0050975 | biological_process | sensory perception of touch |
| D | 0050976 | biological_process | detection of mechanical stimulus involved in sensory perception of touch |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0071260 | biological_process | cellular response to mechanical stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue PCF A 1801 |
| Chain | Residue |
| A | LEU1420 |
| A | PHE1422 |
| A | HIS1423 |
| A | PCF1802 |
| B | PHE1452 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PCF A 1802 |
| Chain | Residue |
| A | SER1268 |
| A | LEU1272 |
| A | PCF1801 |
| B | PCF1805 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue PCF A 1803 |
| Chain | Residue |
| A | TYR1528 |
| A | TYR1532 |
| A | LYS1535 |
| A | ILE1536 |
| D | HIS1492 |
| D | ILE1494 |
| D | GLU1498 |
| D | PCF1806 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PCF A 1804 |
| Chain | Residue |
| A | TRP1394 |
| A | THR1396 |
| A | PCF1806 |
| B | ASN1467 |
| B | LEU1533 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue PCF A 1805 |
| Chain | Residue |
| A | PHE1486 |
| A | VAL1489 |
| A | HIS1492 |
| A | PRO1493 |
| A | ILE1494 |
| D | SER1319 |
| D | THR1324 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue PCF A 1806 |
| Chain | Residue |
| A | PCF1804 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue PCF A 1807 |
| Chain | Residue |
| A | GLY1363 |
| A | LEU1364 |
| A | ALA1430 |
| A | ILE1431 |
| A | ILE1433 |
| A | GLY1434 |
| A | LEU1437 |
| A | PCF1808 |
| B | ILE1540 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue PCF A 1808 |
| Chain | Residue |
| A | LEU1437 |
| A | LYS1438 |
| A | ALA1441 |
| A | LEU1444 |
| A | PCF1807 |
| B | PCF1808 |
| D | LEU1425 |
| D | PCF1808 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue PCF B 1801 |
| Chain | Residue |
| B | TRP1394 |
| B | THR1396 |
| B | PCF1803 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PCF B 1802 |
| Chain | Residue |
| A | SER1319 |
| A | THR1324 |
| B | PHE1486 |
| B | VAL1489 |
| B | HIS1492 |
| B | PRO1493 |
| B | ILE1494 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue PCF B 1803 |
| Chain | Residue |
| B | PCF1801 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PCF B 1804 |
| Chain | Residue |
| B | GLY1363 |
| B | LEU1364 |
| B | ALA1430 |
| B | ILE1433 |
| B | GLY1434 |
| B | LEU1437 |
| B | PCF1805 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue PCF B 1805 |
| Chain | Residue |
| A | LEU1425 |
| A | PCF1802 |
| B | LEU1437 |
| B | LYS1438 |
| B | ALA1441 |
| B | LEU1444 |
| B | PCF1804 |
| C | PCF1801 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PCF B 1806 |
| Chain | Residue |
| B | LEU1420 |
| B | PHE1422 |
| B | HIS1423 |
| B | PCF1807 |
| C | PHE1452 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue PCF B 1807 |
| Chain | Residue |
| B | SER1268 |
| B | LEU1272 |
| B | PCF1806 |
| C | PCF1806 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue PCF B 1808 |
| Chain | Residue |
| A | HIS1492 |
| A | ILE1494 |
| A | GLU1498 |
| A | PCF1808 |
| B | TYR1528 |
| B | TYR1532 |
| B | LYS1535 |
| B | ILE1536 |
| B | LEU1543 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue PCF C 1801 |
| Chain | Residue |
| C | ILE1540 |
| B | HIS1492 |
| B | ILE1494 |
| B | GLU1498 |
| B | PCF1805 |
| C | TYR1528 |
| C | TYR1532 |
| C | LYS1535 |
| C | ILE1536 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue PCF C 1802 |
| Chain | Residue |
| C | TRP1394 |
| C | THR1396 |
| C | PCF1804 |
| D | ASN1467 |
| D | TRP1529 |
| D | LEU1533 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue PCF C 1803 |
| Chain | Residue |
| B | SER1319 |
| B | THR1324 |
| C | PHE1486 |
| C | VAL1489 |
| C | HIS1492 |
| C | PRO1493 |
| C | ILE1494 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue PCF C 1804 |
| Chain | Residue |
| C | TRP1394 |
| C | PCF1802 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue PCF C 1805 |
| Chain | Residue |
| C | GLY1363 |
| C | LEU1364 |
| C | ALA1430 |
| C | ILE1431 |
| C | ILE1433 |
| C | GLY1434 |
| C | LEU1437 |
| C | PCF1806 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue PCF C 1806 |
| Chain | Residue |
| B | LEU1425 |
| B | PCF1807 |
| C | LEU1437 |
| C | LYS1438 |
| C | ALA1441 |
| C | LEU1444 |
| C | PCF1805 |
| D | PCF1801 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue PCF C 1807 |
| Chain | Residue |
| C | LEU1420 |
| C | PHE1422 |
| C | HIS1423 |
| C | PCF1808 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue PCF C 1808 |
| Chain | Residue |
| C | SER1268 |
| C | LEU1272 |
| C | PCF1807 |
| D | PCF1806 |
| site_id | AE7 |
| Number of Residues | 10 |
| Details | binding site for residue PCF D 1801 |
| Chain | Residue |
| C | HIS1492 |
| C | ILE1494 |
| C | GLU1498 |
| C | PCF1806 |
| D | TYR1528 |
| D | TYR1532 |
| D | LYS1535 |
| D | ILE1536 |
| D | ILE1540 |
| D | LEU1543 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue PCF D 1802 |
| Chain | Residue |
| D | TRP1394 |
| D | THR1396 |
| D | PCF1804 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue PCF D 1803 |
| Chain | Residue |
| C | SER1319 |
| C | THR1324 |
| D | PHE1486 |
| D | VAL1489 |
| D | HIS1492 |
| D | PRO1493 |
| D | ILE1494 |
| site_id | AF1 |
| Number of Residues | 1 |
| Details | binding site for residue PCF D 1804 |
| Chain | Residue |
| D | PCF1802 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue PCF D 1805 |
| Chain | Residue |
| D | GLY1363 |
| D | LEU1364 |
| D | ALA1430 |
| D | ILE1433 |
| D | GLY1434 |
| D | LEU1437 |
| D | PCF1806 |
| site_id | AF3 |
| Number of Residues | 8 |
| Details | binding site for residue PCF D 1806 |
| Chain | Residue |
| A | PCF1803 |
| C | LEU1425 |
| C | PCF1808 |
| D | LEU1437 |
| D | LYS1438 |
| D | ALA1441 |
| D | LEU1444 |
| D | PCF1805 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue PCF D 1807 |
| Chain | Residue |
| A | PHE1452 |
| D | LEU1420 |
| D | PHE1422 |
| D | HIS1423 |
| D | PCF1808 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue PCF D 1808 |
| Chain | Residue |
| A | PCF1808 |
| D | SER1268 |
| D | LEU1272 |
| D | PCF1807 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. HlAARrrDVDMV |
| Chain | Residue | Details |
| A | HIS273-VAL284 |
