Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5VKQ

Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001964	biological_process	startle response
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006816	biological_process	calcium ion transport
A	0007605	biological_process	sensory perception of sound
A	0007638	biological_process	mechanosensory behavior
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0010996	biological_process	response to auditory stimulus
A	0016020	cellular_component	membrane
A	0030425	cellular_component	dendrite
A	0030506	molecular_function	ankyrin binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034703	cellular_component	cation channel complex
A	0040011	biological_process	locomotion
A	0043025	cellular_component	neuronal cell body
A	0050954	biological_process	sensory perception of mechanical stimulus
A	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
A	0050975	biological_process	sensory perception of touch
A	0050976	biological_process	detection of mechanical stimulus involved in sensory perception of touch
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071260	biological_process	cellular response to mechanical stimulus
B	0001964	biological_process	startle response
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006816	biological_process	calcium ion transport
B	0007605	biological_process	sensory perception of sound
B	0007638	biological_process	mechanosensory behavior
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0010996	biological_process	response to auditory stimulus
B	0016020	cellular_component	membrane
B	0030425	cellular_component	dendrite
B	0030506	molecular_function	ankyrin binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034703	cellular_component	cation channel complex
B	0040011	biological_process	locomotion
B	0043025	cellular_component	neuronal cell body
B	0050954	biological_process	sensory perception of mechanical stimulus
B	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
B	0050975	biological_process	sensory perception of touch
B	0050976	biological_process	detection of mechanical stimulus involved in sensory perception of touch
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0071260	biological_process	cellular response to mechanical stimulus
C	0001964	biological_process	startle response
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006816	biological_process	calcium ion transport
C	0007605	biological_process	sensory perception of sound
C	0007638	biological_process	mechanosensory behavior
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0010996	biological_process	response to auditory stimulus
C	0016020	cellular_component	membrane
C	0030425	cellular_component	dendrite
C	0030506	molecular_function	ankyrin binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034703	cellular_component	cation channel complex
C	0040011	biological_process	locomotion
C	0043025	cellular_component	neuronal cell body
C	0050954	biological_process	sensory perception of mechanical stimulus
C	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
C	0050975	biological_process	sensory perception of touch
C	0050976	biological_process	detection of mechanical stimulus involved in sensory perception of touch
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0071260	biological_process	cellular response to mechanical stimulus
D	0001964	biological_process	startle response
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0006816	biological_process	calcium ion transport
D	0007605	biological_process	sensory perception of sound
D	0007638	biological_process	mechanosensory behavior
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0010996	biological_process	response to auditory stimulus
D	0016020	cellular_component	membrane
D	0030425	cellular_component	dendrite
D	0030506	molecular_function	ankyrin binding
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034703	cellular_component	cation channel complex
D	0040011	biological_process	locomotion
D	0043025	cellular_component	neuronal cell body
D	0050954	biological_process	sensory perception of mechanical stimulus
D	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
D	0050975	biological_process	sensory perception of touch
D	0050976	biological_process	detection of mechanical stimulus involved in sensory perception of touch
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0071260	biological_process	cellular response to mechanical stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PCF A 1801

Chain	Residue
A	LEU1420
A	PHE1422
A	HIS1423
A	PCF1802
B	PHE1452

site_id	AC2
Number of Residues	4
Details	binding site for residue PCF A 1802

Chain	Residue
A	SER1268
A	LEU1272
A	PCF1801
B	PCF1805

site_id	AC3
Number of Residues	8
Details	binding site for residue PCF A 1803

Chain	Residue
A	TYR1528
A	TYR1532
A	LYS1535
A	ILE1536
D	HIS1492
D	ILE1494
D	GLU1498
D	PCF1806

site_id	AC4
Number of Residues	5
Details	binding site for residue PCF A 1804

Chain	Residue
A	TRP1394
A	THR1396
A	PCF1806
B	ASN1467
B	LEU1533

site_id	AC5
Number of Residues	7
Details	binding site for residue PCF A 1805

Chain	Residue
A	PHE1486
A	VAL1489
A	HIS1492
A	PRO1493
A	ILE1494
D	SER1319
D	THR1324

site_id	AC6
Number of Residues	1
Details	binding site for residue PCF A 1806

Chain	Residue
A	PCF1804

site_id	AC7
Number of Residues	9
Details	binding site for residue PCF A 1807

Chain	Residue
A	GLY1363
A	LEU1364
A	ALA1430
A	ILE1431
A	ILE1433
A	GLY1434
A	LEU1437
A	PCF1808
B	ILE1540

site_id	AC8
Number of Residues	8
Details	binding site for residue PCF A 1808

Chain	Residue
A	LEU1437
A	LYS1438
A	ALA1441
A	LEU1444
A	PCF1807
B	PCF1808
D	LEU1425
D	PCF1808

site_id	AC9
Number of Residues	3
Details	binding site for residue PCF B 1801

Chain	Residue
B	TRP1394
B	THR1396
B	PCF1803

site_id	AD1
Number of Residues	7
Details	binding site for residue PCF B 1802

Chain	Residue
A	SER1319
A	THR1324
B	PHE1486
B	VAL1489
B	HIS1492
B	PRO1493
B	ILE1494

site_id	AD2
Number of Residues	1
Details	binding site for residue PCF B 1803

Chain	Residue
B	PCF1801

site_id	AD3
Number of Residues	7
Details	binding site for residue PCF B 1804

Chain	Residue
B	GLY1363
B	LEU1364
B	ALA1430
B	ILE1433
B	GLY1434
B	LEU1437
B	PCF1805

site_id	AD4
Number of Residues	8
Details	binding site for residue PCF B 1805

Chain	Residue
A	LEU1425
A	PCF1802
B	LEU1437
B	LYS1438
B	ALA1441
B	LEU1444
B	PCF1804
C	PCF1801

site_id	AD5
Number of Residues	5
Details	binding site for residue PCF B 1806

Chain	Residue
B	LEU1420
B	PHE1422
B	HIS1423
B	PCF1807
C	PHE1452

site_id	AD6
Number of Residues	4
Details	binding site for residue PCF B 1807

Chain	Residue
B	SER1268
B	LEU1272
B	PCF1806
C	PCF1806

site_id	AD7
Number of Residues	9
Details	binding site for residue PCF B 1808

Chain	Residue
A	HIS1492
A	ILE1494
A	GLU1498
A	PCF1808
B	TYR1528
B	TYR1532
B	LYS1535
B	ILE1536
B	LEU1543

site_id	AD8
Number of Residues	9
Details	binding site for residue PCF C 1801

Chain	Residue
C	ILE1540
B	HIS1492
B	ILE1494
B	GLU1498
B	PCF1805
C	TYR1528
C	TYR1532
C	LYS1535
C	ILE1536

site_id	AD9
Number of Residues	6
Details	binding site for residue PCF C 1802

Chain	Residue
C	TRP1394
C	THR1396
C	PCF1804
D	ASN1467
D	TRP1529
D	LEU1533

site_id	AE1
Number of Residues	7
Details	binding site for residue PCF C 1803

Chain	Residue
B	SER1319
B	THR1324
C	PHE1486
C	VAL1489
C	HIS1492
C	PRO1493
C	ILE1494

site_id	AE2
Number of Residues	2
Details	binding site for residue PCF C 1804

Chain	Residue
C	TRP1394
C	PCF1802

site_id	AE3
Number of Residues	8
Details	binding site for residue PCF C 1805

Chain	Residue
C	GLY1363
C	LEU1364
C	ALA1430
C	ILE1431
C	ILE1433
C	GLY1434
C	LEU1437
C	PCF1806

site_id	AE4
Number of Residues	8
Details	binding site for residue PCF C 1806

Chain	Residue
B	LEU1425
B	PCF1807
C	LEU1437
C	LYS1438
C	ALA1441
C	LEU1444
C	PCF1805
D	PCF1801

site_id	AE5
Number of Residues	4
Details	binding site for residue PCF C 1807

Chain	Residue
C	LEU1420
C	PHE1422
C	HIS1423
C	PCF1808

site_id	AE6
Number of Residues	4
Details	binding site for residue PCF C 1808

Chain	Residue
C	SER1268
C	LEU1272
C	PCF1807
D	PCF1806

site_id	AE7
Number of Residues	10
Details	binding site for residue PCF D 1801

Chain	Residue
C	HIS1492
C	ILE1494
C	GLU1498
C	PCF1806
D	TYR1528
D	TYR1532
D	LYS1535
D	ILE1536
D	ILE1540
D	LEU1543

site_id	AE8
Number of Residues	3
Details	binding site for residue PCF D 1802

Chain	Residue
D	TRP1394
D	THR1396
D	PCF1804

site_id	AE9
Number of Residues	7
Details	binding site for residue PCF D 1803

Chain	Residue
C	SER1319
C	THR1324
D	PHE1486
D	VAL1489
D	HIS1492
D	PRO1493
D	ILE1494

site_id	AF1
Number of Residues	1
Details	binding site for residue PCF D 1804

Chain	Residue
D	PCF1802

site_id	AF2
Number of Residues	7
Details	binding site for residue PCF D 1805

Chain	Residue
D	GLY1363
D	LEU1364
D	ALA1430
D	ILE1433
D	GLY1434
D	LEU1437
D	PCF1806

site_id	AF3
Number of Residues	8
Details	binding site for residue PCF D 1806

Chain	Residue
A	PCF1803
C	LEU1425
C	PCF1808
D	LEU1437
D	LYS1438
D	ALA1441
D	LEU1444
D	PCF1805

site_id	AF4
Number of Residues	5
Details	binding site for residue PCF D 1807

Chain	Residue
A	PHE1452
D	LEU1420
D	PHE1422
D	HIS1423
D	PCF1808

site_id	AF5
Number of Residues	4
Details	binding site for residue PCF D 1808

Chain	Residue
A	PCF1808
D	SER1268
D	LEU1272
D	PCF1807

Functional Information from PROSITE/UniProt

site_id	PS00794
Number of Residues	12
Details	HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. HlAARrrDVDMV

Chain	Residue	Details
A	HIS273-VAL284

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)