5VJZ

Joint X-ray/neutron structure of aspartate aminotransferase with alpha-methyl-aspartate at pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
A	0004609	molecular_function	phosphatidylserine decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006107	biological_process	oxaloacetate metabolic process
A	0006114	biological_process	glycerol biosynthetic process
A	0006531	biological_process	aspartate metabolic process
A	0006532	biological_process	aspartate biosynthetic process
A	0006533	biological_process	aspartate catabolic process
A	0006536	biological_process	glutamate metabolic process
A	0007219	biological_process	Notch signaling pathway
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0019550	biological_process	glutamate catabolic process to aspartate
A	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
A	0032869	biological_process	cellular response to insulin stimulus
A	0047801	molecular_function	L-cysteine transaminase activity
A	0051384	biological_process	response to glucocorticoid
A	0055089	biological_process	fatty acid homeostasis
B	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
B	0004609	molecular_function	phosphatidylserine decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006107	biological_process	oxaloacetate metabolic process
B	0006114	biological_process	glycerol biosynthetic process
B	0006531	biological_process	aspartate metabolic process
B	0006532	biological_process	aspartate biosynthetic process
B	0006533	biological_process	aspartate catabolic process
B	0006536	biological_process	glutamate metabolic process
B	0007219	biological_process	Notch signaling pathway
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0019550	biological_process	glutamate catabolic process to aspartate
B	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
B	0032869	biological_process	cellular response to insulin stimulus
B	0047801	molecular_function	L-cysteine transaminase activity
B	0051384	biological_process	response to glucocorticoid
B	0055089	biological_process	fatty acid homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue PLA A 501

Chain	Residue
A	GLY38
A	SER257
A	LYS258
A	ARG266
A	ARG386
B	TYR70
B	ARG292
B	DOD529
A	GLY107
A	GLY108
A	THR109
A	TRP140
A	ASN194
A	ASP222
A	TYR225
A	SER255

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Functional Information from PROSITE/UniProt

site_id	PS00105
Number of Residues	14
Details	AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKnfGLyNERVG

Chain	Residue	Details
A	SER255-GLY268
B	SER255-GLY268

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
B	GLY38
B	TRP140
B	ASN194
B	ARG386

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-(pyridoxal phosphate)lysine

Chain	Residue	Details
B	LLP258

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