5VHP
Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| G | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| G | 0000502 | cellular_component | proteasome complex |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0005856 | cellular_component | cytoskeleton |
| G | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| G | 0006915 | biological_process | apoptotic process |
| G | 0008540 | cellular_component | proteasome regulatory particle, base subcomplex |
| G | 0030307 | biological_process | positive regulation of cell growth |
| G | 0031398 | biological_process | positive regulation of protein ubiquitination |
| G | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| G | 0043066 | biological_process | negative regulation of apoptotic process |
| G | 0043409 | biological_process | negative regulation of MAPK cascade |
| G | 0043518 | biological_process | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| G | 0045737 | biological_process | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| G | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| G | 0070682 | biological_process | proteasome regulatory particle assembly |
| G | 0090201 | biological_process | negative regulation of release of cytochrome c from mitochondria |
| f | 0000502 | cellular_component | proteasome complex |
| f | 0030234 | molecular_function | enzyme regulator activity |
| f | 0042176 | biological_process | regulation of protein catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. VkVIaATNrvdiLDpALl.R |
| Chain | Residue | Details |
| F | VAL326-ARG344 | |
| A | ILE315-ARG333 | |
| C | ILE289-ARG307 | |
| E | VAL273-ARG291 | |
| D | VAL305-ARG323 | |
| B | VAL325-ARG343 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"ANK 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Repeat: {"description":"ANK 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 187 |
| Details | Region: {"description":"Interaction with RELA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 55 |
| Details | Region: {"description":"Interaction with RB1","evidences":[{"source":"PubMed","id":"10613832","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"PC 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"PC 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"PC 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"PC 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
