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5VHM

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0016887molecular_functionATP hydrolysis activity
B0005524molecular_functionATP binding
B0016887molecular_functionATP hydrolysis activity
C0005524molecular_functionATP binding
C0016887molecular_functionATP hydrolysis activity
D0005524molecular_functionATP binding
D0016887molecular_functionATP hydrolysis activity
E0005524molecular_functionATP binding
E0016887molecular_functionATP hydrolysis activity
f0000502cellular_componentproteasome complex
f0005515molecular_functionprotein binding
f0005576cellular_componentextracellular region
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005829cellular_componentcytosol
f0005838cellular_componentproteasome regulatory particle
f0008540cellular_componentproteasome regulatory particle, base subcomplex
f0016020cellular_componentmembrane
f0022624cellular_componentproteasome accessory complex
f0030234molecular_functionenzyme regulator activity
f0034515cellular_componentproteasome storage granule
f0034774cellular_componentsecretory granule lumen
f0042176biological_processregulation of protein catabolic process
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0070062cellular_componentextracellular exosome
f1904813cellular_componentficolin-1-rich granule lumen
F0005524molecular_functionATP binding
F0016887molecular_functionATP hydrolysis activity
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0000502cellular_componentproteasome complex
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0006357biological_processregulation of transcription by RNA polymerase II
G0006915biological_processapoptotic process
G0007253biological_processcytoplasmic sequestering of NF-kappaB
G0008092molecular_functioncytoskeletal protein binding
G0008134molecular_functiontranscription factor binding
G0008540cellular_componentproteasome regulatory particle, base subcomplex
G0030307biological_processpositive regulation of cell growth
G0030674molecular_functionprotein-macromolecule adaptor activity
G0031398biological_processpositive regulation of protein ubiquitination
G0032088biological_processnegative regulation of NF-kappaB transcription factor activity
G0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
G0043005cellular_componentneuron projection
G0043066biological_processnegative regulation of apoptotic process
G0043409biological_processnegative regulation of MAPK cascade
G0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
G0044325molecular_functiontransmembrane transporter binding
G0045111cellular_componentintermediate filament cytoskeleton
G0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
G0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
G0070682biological_processproteasome regulatory particle assembly
G0072659biological_processprotein localization to plasma membrane
G0090201biological_processnegative regulation of release of cytochrome c from mitochondria
Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IkVImATNridiLDsALl.R
ChainResidueDetails
CILE289-ARG307
DVAL305-ARG323
EVAL273-ARG291
AILE315-ARG333
BVAL325-ARG343
FVAL326-ARG344

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17323924, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
fSER16

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17323924, ECO:0007744|PubMed:20068231
ChainResidueDetails
fTHR24

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17323924
ChainResidueDetails
fSER29

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
fSER147

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:17323924
ChainResidueDetails
fTYR194

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
fSER361

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
fSER363

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8VDM4
ChainResidueDetails
fLYS551

219140

PDB entries from 2024-05-01

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