5VHJ

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
D	0005524	molecular_function	ATP binding
D	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
f	0000502	cellular_component	proteasome complex
f	0030234	molecular_function	enzyme regulator activity
f	0042176	biological_process	regulation of protein catabolic process
F	0005524	molecular_function	ATP binding
F	0016887	molecular_function	ATP hydrolysis activity
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000502	cellular_component	proteasome complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006915	biological_process	apoptotic process
G	0007253	biological_process	cytoplasmic sequestering of NF-kappaB
G	0008092	molecular_function	cytoskeletal protein binding
G	0008134	molecular_function	transcription factor binding
G	0008540	cellular_component	proteasome regulatory particle, base subcomplex
G	0030307	biological_process	positive regulation of cell growth
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031398	biological_process	positive regulation of protein ubiquitination
G	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0043005	cellular_component	neuron projection
G	0043066	biological_process	negative regulation of apoptotic process
G	0043409	biological_process	negative regulation of MAPK cascade
G	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
G	0044325	molecular_function	transmembrane transporter binding
G	0045111	cellular_component	intermediate filament cytoskeleton
G	0045737	biological_process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0070682	biological_process	proteasome regulatory particle assembly
G	0072659	biological_process	protein localization to plasma membrane
G	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkVImATNridiLDsALl.R

Chain	Residue	Details
C	ILE289-ARG307
F	VAL326-ARG344
B	VAL325-ARG343
D	VAL305-ARG323
A	ILE315-ARG333
E	VAL273-ARG291

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
f	SER147

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:17323924

Chain	Residue	Details
f	TYR194

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
f	SER361

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
f	SER363

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8VDM4

Chain	Residue	Details
f	LYS551

---