Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5VGZ

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0005838	cellular_component	proteasome regulatory particle
U	0008540	cellular_component	proteasome regulatory particle, base subcomplex
U	0016020	cellular_component	membrane
U	0022624	cellular_component	proteasome accessory complex
U	0030234	molecular_function	enzyme regulator activity
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0034515	cellular_component	proteasome storage granule
U	0035578	cellular_component	azurophil granule lumen
U	0042176	biological_process	regulation of protein catabolic process
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0005838	cellular_component	proteasome regulatory particle
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016020	cellular_component	membrane
V	0022624	cellular_component	proteasome accessory complex
V	0030234	molecular_function	enzyme regulator activity
V	0032991	cellular_component	protein-containing complex
V	0034774	cellular_component	secretory granule lumen
V	0042176	biological_process	regulation of protein catabolic process
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0070062	cellular_component	extracellular exosome
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005838	cellular_component	proteasome regulatory particle
W	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
W	0016020	cellular_component	membrane
W	0022624	cellular_component	proteasome accessory complex
W	0034774	cellular_component	secretory granule lumen
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0070062	cellular_component	extracellular exosome
W	1904813	cellular_component	ficolin-1-rich granule lumen
X	0000502	cellular_component	proteasome complex
X	0005198	molecular_function	structural molecule activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005838	cellular_component	proteasome regulatory particle
X	0006511	biological_process	ubiquitin-dependent protein catabolic process
X	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
X	0016020	cellular_component	membrane
X	0022624	cellular_component	proteasome accessory complex
X	0032991	cellular_component	protein-containing complex
X	0034774	cellular_component	secretory granule lumen
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043248	biological_process	proteasome assembly
X	0048863	biological_process	stem cell differentiation
X	1904813	cellular_component	ficolin-1-rich granule lumen
Y	0000502	cellular_component	proteasome complex
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005654	cellular_component	nucleoplasm
Y	0005829	cellular_component	cytosol
Y	0005838	cellular_component	proteasome regulatory particle
Y	0022624	cellular_component	proteasome accessory complex
Y	0034774	cellular_component	secretory granule lumen
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	1904813	cellular_component	ficolin-1-rich granule lumen
Z	0005838	cellular_component	proteasome regulatory particle
Z	0008233	molecular_function	peptidase activity
Z	0008237	molecular_function	metallopeptidase activity
a	0000502	cellular_component	proteasome complex
a	0005198	molecular_function	structural molecule activity
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005829	cellular_component	cytosol
a	0005838	cellular_component	proteasome regulatory particle
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0007127	biological_process	meiosis I
a	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
a	0016020	cellular_component	membrane
a	0022624	cellular_component	proteasome accessory complex
a	0034774	cellular_component	secretory granule lumen
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	1904813	cellular_component	ficolin-1-rich granule lumen
c	0000502	cellular_component	proteasome complex
c	0000724	biological_process	double-strand break repair via homologous recombination
c	0005515	molecular_function	protein binding
c	0005576	cellular_component	extracellular region
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005829	cellular_component	cytosol
c	0006281	biological_process	DNA repair
c	0006303	biological_process	double-strand break repair via nonhomologous end joining
c	0006508	biological_process	proteolysis
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0006974	biological_process	DNA damage response
c	0008233	molecular_function	peptidase activity
c	0008237	molecular_function	metallopeptidase activity
c	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
c	0016787	molecular_function	hydrolase activity
c	0022624	cellular_component	proteasome accessory complex
c	0031597	cellular_component	cytosolic proteasome complex
c	0034774	cellular_component	secretory granule lumen
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0045471	biological_process	response to ethanol
c	0046872	molecular_function	metal ion binding
c	0061133	molecular_function	endopeptidase activator activity
c	0061136	biological_process	regulation of proteasomal protein catabolic process
c	0061578	molecular_function	K63-linked deubiquitinase activity
c	0070536	biological_process	protein K63-linked deubiquitination
c	0070628	molecular_function	proteasome binding
c	0140492	molecular_function	metal-dependent deubiquitinase activity
c	1904813	cellular_component	ficolin-1-rich granule lumen
d	0005838	cellular_component	proteasome regulatory particle
d	0006508	biological_process	proteolysis
e	0000502	cellular_component	proteasome complex
e	0000724	biological_process	double-strand break repair via homologous recombination
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005829	cellular_component	cytosol
e	0006406	biological_process	mRNA export from nucleus
e	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
e	0032039	cellular_component	integrator complex
e	0032991	cellular_component	protein-containing complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0043248	biological_process	proteasome assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue ZN c 400

Chain	Residue
c	PHE118

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
d	SER13
c	HIS115
c	ASP126

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
d	LYS204
W	LYS368

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17323924

Chain	Residue	Details
c	SER224

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
c	THR266

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:17323924, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
U	THR311

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17323924, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
U	SER315

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q3TXS7

Chain	Residue	Details
U	LYS720

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
U	THR830

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
U	SER834

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)