5VFM
Crystal structure of BnSP-7 from Bothrops pauloensis complexed with p-coumaric acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0050482 | biological_process | arachidonate secretion |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ME2 B 201 |
| Chain | Residue |
| A | LEU121 |
| B | LEU2 |
| B | GLY6 |
| B | ALA19 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | LYS16 |
| B | ASN17 |
| B | LYS20 |
| B | SO4203 |
| B | HOH305 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| B | LYS16 |
| B | LYS20 |
| B | LYS115 |
| B | ARG118 |
| B | SO4202 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 204 |
| Chain | Residue |
| B | GLY33 |
| B | ARG34 |
| B | LYS53 |
| B | HOH309 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 205 |
| Chain | Residue |
| B | GLU4 |
| B | LYS7 |
| B | ARG72 |
| B | TYR73 |
| B | HOH303 |
| B | HOH324 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue ME2 A 201 |
| Chain | Residue |
| A | LEU2 |
| A | GLY6 |
| A | HOH378 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | LYS16 |
| A | ASN17 |
| A | HC4207 |
| A | HOH304 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | GLY33 |
| A | ARG34 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 204 |
| Chain | Residue |
| A | PRO37 |
| A | ARG43 |
| A | HOH352 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 205 |
| Chain | Residue |
| A | ILE104 |
| A | ARG107 |
| A | HOH313 |
| A | HOH338 |
| A | HOH342 |
| A | HOH351 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 206 |
| Chain | Residue |
| A | CYS51 |
| A | LYS57 |
| A | HOH306 |
| A | HOH308 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue HC4 A 207 |
| Chain | Residue |
| A | LYS16 |
| A | LYS20 |
| A | LYS115 |
| A | ARG118 |
| A | TYR119 |
| A | SO4202 |
| B | LYS20 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Important for membrane-damaging activities in eukaryotes and bacteria; heparin-binding","evidences":[{"source":"UniProtKB","id":"P24605","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"PubMed","id":"28751219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"28751219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important residue of the cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"28751219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Hydrophobic membrane-disruption site (MDiS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"28751219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
