5VDF

Crystal Structure of Cu(I)-loaded yeast Atx1: Crystal Form II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006825	biological_process	copper ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0016531	molecular_function	copper chaperone activity
A	0034599	biological_process	cellular response to oxidative stress
A	0046872	molecular_function	metal ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006825	biological_process	copper ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0016531	molecular_function	copper chaperone activity
B	0034599	biological_process	cellular response to oxidative stress
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006825	biological_process	copper ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0016531	molecular_function	copper chaperone activity
C	0034599	biological_process	cellular response to oxidative stress
C	0046872	molecular_function	metal ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006825	biological_process	copper ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0016531	molecular_function	copper chaperone activity
D	0034599	biological_process	cellular response to oxidative stress
D	0046872	molecular_function	metal ion binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006825	biological_process	copper ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0016531	molecular_function	copper chaperone activity
E	0034599	biological_process	cellular response to oxidative stress
E	0046872	molecular_function	metal ion binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006825	biological_process	copper ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0016531	molecular_function	copper chaperone activity
F	0034599	biological_process	cellular response to oxidative stress
F	0046872	molecular_function	metal ion binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006825	biological_process	copper ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0016531	molecular_function	copper chaperone activity
G	0034599	biological_process	cellular response to oxidative stress
G	0046872	molecular_function	metal ion binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006825	biological_process	copper ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0016531	molecular_function	copper chaperone activity
H	0034599	biological_process	cellular response to oxidative stress
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CU1 A 101

Chain	Residue
A	CYS15
A	CYS18
B	CYS15
B	CYS18

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site_id	AC2
Number of Residues	4
Details	binding site for residue CU1 C 101

Chain	Residue
C	CYS15
C	CYS18
D	CYS15
D	CYS18

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CU1 E 101

Chain	Residue
E	CYS18
F	CYS15
F	CYS18
E	CYS15

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CU1 G 101

Chain	Residue
G	CYS15
G	CYS18
H	CYS15
H	CYS18

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Functional Information from PROSITE/UniProt

site_id	PS01047
Number of Residues	31
Details	HMA_1 Heavy-metal-associated domain. NvVMtCsGCsgaVNkvLtklepdvskidIsL

Chain	Residue	Details
A	ASN10-LEU40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00280, ECO:0000269|PubMed:11327811, ECO:0000269|PubMed:19965379, ECO:0000269|PubMed:28865724, ECO:0007744|PDB:1FD8, ECO:0007744|PDB:3K7R, ECO:0007744|PDB:5VDE, ECO:0007744|PDB:5VDF

Chain	Residue	Details
A	CYS15
E	CYS18
F	CYS15
F	CYS18
G	CYS15
G	CYS18
H	CYS15
H	CYS18
A	CYS18
B	CYS15
B	CYS18
C	CYS15
C	CYS18
D	CYS15
D	CYS18
E	CYS15

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