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5VBO

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH LRRK2-IN-1

Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 4K4 A 201
ChainResidue
ATRP81
AILE146
AEDO207
AEDO208
AHOH323
AHOH361
APRO82
APHE83
AGLN85
AVAL87
ALEU94
AGLU115
AASN117
AASN140

site_idAC2
Number of Residues3
Detailsbinding site for residue CL A 202
ChainResidue
ALYS57
ALYS99
ALYS102

site_idAC3
Number of Residues6
Detailsbinding site for residue CL A 203
ChainResidue
APRO45
APRO47
APRO86
AHOH354
AHOH421
AHOH424

site_idAC4
Number of Residues7
Detailsbinding site for residue EDO A 204
ChainResidue
AARG58
ATHR60
AGLN62
ATRP120
AALA122
AHOH307
AHOH308

site_idAC5
Number of Residues7
Detailsbinding site for residue EDO A 205
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH318
AHOH347

site_idAC6
Number of Residues6
Detailsbinding site for residue EDO A 206
ChainResidue
AGLN78
APHE79
APRO82
AMET149
AHOH324
AHOH325

site_idAC7
Number of Residues6
Detailsbinding site for residue EDO A 207
ChainResidue
AGLN59
AGLN64
AARG68
AGLU151
A4K4201
AHOH358

site_idAC8
Number of Residues6
Detailsbinding site for residue EDO A 208
ChainResidue
AASN140
AASP144
AASP145
AILE146
ALYS155
A4K4201

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

227344

PDB entries from 2024-11-13

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