5VBN

Crystal Structure of human DNA polymerase epsilon B-subunit in complex with C-terminal domain of catalytic subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0008622	cellular_component	epsilon DNA polymerase complex
A	0016604	cellular_component	nuclear body
A	0031981	cellular_component	nuclear lumen
A	0042276	biological_process	error-prone translesion synthesis
A	0043231	cellular_component	intracellular membrane-bounded organelle
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0008622	cellular_component	epsilon DNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006259	biological_process	DNA metabolic process
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006281	biological_process	DNA repair
E	0008622	cellular_component	epsilon DNA polymerase complex
E	0016604	cellular_component	nuclear body
E	0031981	cellular_component	nuclear lumen
E	0042276	biological_process	error-prone translesion synthesis
E	0043231	cellular_component	intracellular membrane-bounded organelle
F	0003677	molecular_function	DNA binding
F	0003887	molecular_function	DNA-directed DNA polymerase activity
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0008622	cellular_component	epsilon DNA polymerase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 601

Chain	Residue
A	ASN421
A	ARG425
A	LYS483
A	HOH758
E	LEU208
E	SER209
E	ARG429

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 2301

Chain	Residue
B	CYS2187
B	CYS2190
B	CYS2158
B	CYS2161

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 2302

Chain	Residue
B	CYS2221
B	CYS2224
B	CYS2236
B	CYS2238

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 E 601

Chain	Residue
A	SER209
A	ARG429
E	ASN421
E	ARG425
E	LYS483
E	HOH724

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN F 2301

Chain	Residue
F	CYS2158
F	CYS2161
F	CYS2187
F	CYS2190

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN F 2302

Chain	Residue
F	CYS2221
F	CYS2224
F	CYS2236
F	CYS2238

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	ZN_FING: CysA-type => ECO:0000250|UniProtKB:P15436

Chain	Residue	Details
B	CYS2158-CYS2190
F	CYS2158-CYS2190

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P15436

Chain	Residue	Details
B	CYS2158
F	CYS2161
F	CYS2187
F	CYS2190
F	CYS2221
F	CYS2224
F	CYS2236
F	CYS2238
B	CYS2161
B	CYS2187
B	CYS2190
B	CYS2221
B	CYS2224
B	CYS2236
B	CYS2238
F	CYS2158

---