5V8X

Mutant Structures of Streptococcus Agalactiae GBS Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005737	cellular_component	cytoplasm
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005737	cellular_component	cytoplasm
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005737	cellular_component	cytoplasm
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0005737	cellular_component	cytoplasm
D	0006006	biological_process	glucose metabolic process
D	0006096	biological_process	glycolytic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue NAD A 401

Chain	Residue
A	GLY9
A	THR97
A	GLY98
A	PHE100
A	THR121
A	ALA122
A	CYS152
A	ASN316
A	TYR320
C	PRO191
A	PHE10
A	GLY11
A	ARG12
A	ILE13
A	ASP34
A	LEU35
A	ARG78
A	ALA96

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 402

Chain	Residue
A	ILE21
A	VAL24
A	VAL27

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site_id	AC3
Number of Residues	19
Details	binding site for residue NAD B 401

Chain	Residue
B	ASN8
B	GLY9
B	GLY11
B	ARG12
B	ILE13
B	ASP34
B	LEU35
B	ARG78
B	ALA96
B	THR97
B	GLY98
B	PHE99
B	PHE100
B	THR121
B	ALA122
B	CYS152
B	ASN316
B	TYR320
D	PRO191

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG B 402

Chain	Residue
B	ILE21
B	VAL24
B	VAL27

---

site_id	AC5
Number of Residues	19
Details	binding site for residue NAD C 401

Chain	Residue
A	PRO191
C	ASN8
C	GLY9
C	PHE10
C	GLY11
C	ARG12
C	ILE13
C	ASP34
C	LEU35
C	GLU77
C	ARG78
C	ALA96
C	THR97
C	GLY98
C	PHE99
C	THR121
C	ALA122
C	CYS152
C	ASN316

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG C 402

Chain	Residue
C	ILE21
C	GLN22
C	VAL24
C	VAL27

---

site_id	AC7
Number of Residues	16
Details	binding site for residue NAD D 401

Chain	Residue
B	PRO191
D	GLY9
D	GLY11
D	ARG12
D	ILE13
D	ASP34
D	LEU35
D	ARG78
D	ALA96
D	GLY98
D	PHE99
D	THR121
D	ALA122
D	CYS152
D	ASN316
D	TYR320

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG D 402

Chain	Residue
D	ILE21
D	VAL24
D	VAL27

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Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA150-LEU157

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