5V7M

PCNA mutant L126A/I128A Protein Defective in Gene Silencing

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0000710	biological_process	meiotic mismatch repair
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005657	cellular_component	replication fork
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006273	biological_process	lagging strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006301	biological_process	postreplication repair
A	0007064	biological_process	mitotic sister chromatid cohesion
A	0019985	biological_process	translesion synthesis
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030466	biological_process	silent mating-type cassette heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0034087	biological_process	establishment of mitotic sister chromatid cohesion
A	0035753	biological_process	maintenance of DNA trinucleotide repeats
A	0042802	molecular_function	identical protein binding
A	0043626	cellular_component	PCNA complex
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0051054	biological_process	positive regulation of DNA metabolic process
A	0070987	biological_process	error-free translesion synthesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 300

Chain	Residue
A	HOH408
A	HOH412
A	HOH428
A	HOH454
A	HOH505
A	HOH512

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Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDHpvtLgmdLtSLsKIL

Chain	Residue	Details
A	ARG61-LEU79

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site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GIiAqAVDdSRVlLVsLeIgveaF

Chain	Residue	Details
A	GLY34-PHE57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: DNA_BIND => ECO:0000255

Chain	Residue	Details
A	ARG61-ARG80

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15166219

Chain	Residue	Details
A	LYS127

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:12226657

Chain	Residue	Details
A	LYS164

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