5V7G
Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with NADPH and oxalate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| C | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| D | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue OXL A 401 |
| Chain | Residue |
| A | GLY71 |
| A | VAL72 |
| A | GLY73 |
| A | LEU96 |
| A | ARG230 |
| A | HIS277 |
| A | NDP402 |
| A | HOH504 |
| A | HOH671 |
| site_id | AC2 |
| Number of Residues | 38 |
| Details | binding site for residue NDP A 402 |
| Chain | Residue |
| A | VAL72 |
| A | VAL100 |
| A | PHE148 |
| A | LEU150 |
| A | GLY151 |
| A | ARG152 |
| A | ILE153 |
| A | THR172 |
| A | ARG173 |
| A | THR174 |
| A | ILE200 |
| A | VAL201 |
| A | PRO202 |
| A | SER206 |
| A | THR207 |
| A | VAL228 |
| A | GLY229 |
| A | ARG230 |
| A | ASP254 |
| A | VAL255 |
| A | HIS277 |
| A | ALA279 |
| A | OXL401 |
| A | HOH503 |
| A | HOH504 |
| A | HOH511 |
| A | HOH536 |
| A | HOH545 |
| A | HOH556 |
| A | HOH590 |
| A | HOH617 |
| A | HOH626 |
| A | HOH636 |
| A | HOH639 |
| A | HOH641 |
| A | HOH644 |
| A | HOH704 |
| A | HOH733 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | VAL95 |
| A | THR285 |
| A | HOH569 |
| A | HOH580 |
| A | HOH620 |
| A | HOH650 |
| B | ARG141 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | ASN13 |
| A | ARG286 |
| A | HOH777 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 405 |
| Chain | Residue |
| A | ALA191 |
| A | GLU192 |
| A | VAL194 |
| A | ALA218 |
| A | LEU219 |
| A | HOH754 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue OXL B 401 |
| Chain | Residue |
| B | GLY71 |
| B | VAL72 |
| B | GLY73 |
| B | LEU96 |
| B | ARG230 |
| B | HIS277 |
| B | NDP402 |
| B | HOH501 |
| B | HOH527 |
| B | HOH557 |
| site_id | AC7 |
| Number of Residues | 34 |
| Details | binding site for residue NDP B 402 |
| Chain | Residue |
| B | HOH552 |
| B | HOH562 |
| B | HOH606 |
| B | HOH610 |
| B | HOH630 |
| B | HOH641 |
| B | HOH651 |
| B | HOH673 |
| B | VAL72 |
| B | GLY73 |
| B | VAL100 |
| B | PHE148 |
| B | LEU150 |
| B | GLY151 |
| B | ARG152 |
| B | ILE153 |
| B | THR172 |
| B | ARG173 |
| B | THR174 |
| B | ILE200 |
| B | VAL201 |
| B | PRO202 |
| B | SER206 |
| B | THR207 |
| B | VAL228 |
| B | GLY229 |
| B | ARG230 |
| B | ASP254 |
| B | HIS277 |
| B | ALA279 |
| B | OXL401 |
| B | HOH505 |
| B | HOH534 |
| B | HOH543 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | ARG141 |
| B | VAL95 |
| B | THR285 |
| B | ALA288 |
| B | HOH511 |
| B | HOH528 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 404 |
| Chain | Residue |
| B | ASN13 |
| B | ARG286 |
| B | HOH713 |
| B | HOH766 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 405 |
| Chain | Residue |
| B | ALA191 |
| B | GLU192 |
| B | VAL194 |
| B | ALA218 |
| B | LEU219 |
| B | HOH725 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue OXL C 401 |
| Chain | Residue |
| C | GLY71 |
| C | VAL72 |
| C | GLY73 |
| C | LEU96 |
| C | ARG230 |
| C | HIS277 |
| C | NDP402 |
| C | HOH503 |
| C | HOH621 |
| site_id | AD3 |
| Number of Residues | 38 |
| Details | binding site for residue NDP C 402 |
| Chain | Residue |
| C | VAL72 |
| C | VAL100 |
| C | PHE148 |
| C | LEU150 |
| C | GLY151 |
| C | ARG152 |
| C | ILE153 |
| C | THR172 |
| C | ARG173 |
| C | THR174 |
| C | ILE200 |
| C | VAL201 |
| C | PRO202 |
| C | SER206 |
| C | THR207 |
| C | VAL228 |
| C | GLY229 |
| C | ARG230 |
| C | ASP254 |
| C | HIS277 |
| C | ALA279 |
| C | OXL401 |
| C | HOH502 |
| C | HOH503 |
| C | HOH504 |
| C | HOH506 |
| C | HOH524 |
| C | HOH545 |
| C | HOH569 |
| C | HOH577 |
| C | HOH594 |
| C | HOH613 |
| C | HOH617 |
| C | HOH618 |
| C | HOH626 |
| C | HOH629 |
| C | HOH647 |
| C | HOH657 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 403 |
| Chain | Residue |
| C | ASN13 |
| C | ARG286 |
| C | HOH766 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 404 |
| Chain | Residue |
| C | ALA191 |
| C | GLU192 |
| C | VAL194 |
| C | ALA218 |
| C | LEU219 |
| C | HOH778 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue OXL D 401 |
| Chain | Residue |
| D | GLY71 |
| D | VAL72 |
| D | GLY73 |
| D | LEU96 |
| D | ARG230 |
| D | HIS277 |
| D | NDP402 |
| D | HOH506 |
| D | HOH519 |
| D | HOH559 |
| site_id | AD7 |
| Number of Residues | 35 |
| Details | binding site for residue NDP D 402 |
| Chain | Residue |
| D | VAL72 |
| D | VAL100 |
| D | PHE148 |
| D | LEU150 |
| D | GLY151 |
| D | ARG152 |
| D | ILE153 |
| D | THR172 |
| D | ARG173 |
| D | THR174 |
| D | ILE200 |
| D | VAL201 |
| D | PRO202 |
| D | SER206 |
| D | THR207 |
| D | VAL228 |
| D | GLY229 |
| D | ARG230 |
| D | ASP254 |
| D | HIS277 |
| D | ALA279 |
| D | OXL401 |
| D | HOH505 |
| D | HOH506 |
| D | HOH509 |
| D | HOH547 |
| D | HOH549 |
| D | HOH565 |
| D | HOH566 |
| D | HOH578 |
| D | HOH583 |
| D | HOH591 |
| D | HOH628 |
| D | HOH645 |
| D | HOH687 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| D | VAL95 |
| D | THR285 |
| D | ALA288 |
| D | HOH609 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 404 |
| Chain | Residue |
| D | ASN13 |
| D | ARG286 |
| D | HOH824 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 405 |
| Chain | Residue |
| D | ALA191 |
| D | GLU192 |
| D | VAL194 |
| D | ALA218 |
| D | LEU219 |
| D | HOH754 |
