5V72
Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with citrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| C | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| D | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | ALA191 |
| A | GLU192 |
| A | VAL194 |
| A | ALA218 |
| A | LEU219 |
| A | HOH668 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | HOH776 |
| A | ASN13 |
| A | ARG286 |
| A | HOH774 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | LEU96 |
| A | GLY229 |
| A | HIS277 |
| A | SER280 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 401 |
| Chain | Residue |
| B | ALA191 |
| B | GLU192 |
| B | VAL194 |
| B | ALA218 |
| B | LEU219 |
| C | HOH667 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | ASN13 |
| B | ARG286 |
| B | HOH699 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue NA C 401 |
| Chain | Residue |
| C | ALA191 |
| C | GLU192 |
| C | VAL194 |
| C | ALA218 |
| C | LEU219 |
| C | HOH615 |
| C | HOH715 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue NA C 402 |
| Chain | Residue |
| C | VAL228 |
| C | GLY229 |
| C | CIT403 |
| C | HOH638 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue CIT C 403 |
| Chain | Residue |
| C | VAL72 |
| C | ILE153 |
| C | VAL228 |
| C | GLY229 |
| C | HIS277 |
| C | ALA279 |
| C | SER280 |
| C | NA402 |
| C | HOH501 |
| C | HOH529 |
| C | HOH562 |
| C | HOH582 |
| C | HOH584 |
| C | HOH634 |
| C | HOH638 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 404 |
| Chain | Residue |
| C | ASN13 |
| C | ARG286 |
| C | HOH776 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 401 |
| Chain | Residue |
| D | ALA191 |
| D | GLU192 |
| D | VAL194 |
| D | ALA218 |
| D | LEU219 |
| D | HOH647 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 402 |
| Chain | Residue |
| D | ASN13 |
| D | ARG286 |
| D | HOH679 |
