5V6Q
Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with NADP and malonate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0005829 | cellular_component | cytosol |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0005829 | cellular_component | cytosol |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
C | 0000166 | molecular_function | nucleotide binding |
C | 0005829 | cellular_component | cytosol |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
C | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
C | 0046872 | molecular_function | metal ion binding |
C | 0051287 | molecular_function | NAD binding |
D | 0000166 | molecular_function | nucleotide binding |
D | 0005829 | cellular_component | cytosol |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
D | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | binding site for residue NAP A 401 |
Chain | Residue |
A | VAL72 |
A | THR174 |
A | ILE200 |
A | VAL201 |
A | PRO202 |
A | SER206 |
A | THR207 |
A | VAL228 |
A | GLY229 |
A | ARG230 |
A | ASP254 |
A | VAL100 |
A | HIS277 |
A | ALA279 |
A | MLA402 |
A | HOH512 |
A | HOH536 |
A | HOH552 |
A | HOH553 |
A | HOH561 |
A | HOH582 |
A | HOH587 |
A | PHE148 |
A | HOH589 |
A | HOH591 |
A | HOH624 |
A | LEU150 |
A | GLY151 |
A | ARG152 |
A | ILE153 |
A | THR172 |
A | ARG173 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue MLA A 402 |
Chain | Residue |
A | GLY71 |
A | VAL72 |
A | GLY73 |
A | LEU96 |
A | ARG230 |
A | HIS277 |
A | SER280 |
A | NAP401 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue NA A 403 |
Chain | Residue |
A | ALA191 |
A | GLU192 |
A | VAL194 |
A | ALA218 |
A | LEU219 |
A | HOH668 |
site_id | AC4 |
Number of Residues | 34 |
Details | binding site for residue NAP B 401 |
Chain | Residue |
B | VAL72 |
B | VAL100 |
B | PHE148 |
B | LEU150 |
B | GLY151 |
B | ARG152 |
B | ILE153 |
B | THR172 |
B | ARG173 |
B | THR174 |
B | ILE200 |
B | VAL201 |
B | PRO202 |
B | SER206 |
B | THR207 |
B | VAL228 |
B | GLY229 |
B | ARG230 |
B | ASP254 |
B | HIS277 |
B | ALA279 |
B | MLA402 |
B | HOH504 |
B | HOH519 |
B | HOH523 |
B | HOH532 |
B | HOH540 |
B | HOH544 |
B | HOH561 |
B | HOH579 |
B | HOH590 |
B | HOH601 |
B | HOH604 |
B | HOH617 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue MLA B 402 |
Chain | Residue |
B | GLY71 |
B | VAL72 |
B | GLY73 |
B | LEU96 |
B | ARG230 |
B | HIS277 |
B | NAP401 |
B | HOH503 |
B | HOH637 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue NA B 403 |
Chain | Residue |
B | ALA191 |
B | GLU192 |
B | VAL194 |
B | ALA218 |
B | LEU219 |
site_id | AC7 |
Number of Residues | 32 |
Details | binding site for residue NAP C 401 |
Chain | Residue |
C | ARG152 |
C | ILE153 |
C | THR172 |
C | ARG173 |
C | THR174 |
C | ILE200 |
C | VAL201 |
C | PRO202 |
C | SER206 |
C | THR207 |
C | VAL228 |
C | GLY229 |
C | ARG230 |
C | ASP254 |
C | HIS277 |
C | ALA279 |
C | MLA402 |
C | HOH505 |
C | HOH513 |
C | HOH525 |
C | HOH545 |
C | HOH553 |
C | HOH567 |
C | HOH583 |
C | HOH615 |
C | HOH620 |
C | HOH621 |
C | VAL72 |
C | VAL100 |
C | PHE148 |
C | LEU150 |
C | GLY151 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue MLA C 402 |
Chain | Residue |
C | GLY71 |
C | VAL72 |
C | GLY73 |
C | LEU96 |
C | ARG230 |
C | HIS277 |
C | NAP401 |
C | HOH501 |
C | HOH582 |
site_id | AC9 |
Number of Residues | 34 |
Details | binding site for residue NAP D 401 |
Chain | Residue |
D | VAL72 |
D | GLY73 |
D | VAL100 |
D | PHE148 |
D | GLY149 |
D | LEU150 |
D | GLY151 |
D | ARG152 |
D | ILE153 |
D | THR172 |
D | ARG173 |
D | THR174 |
D | ILE200 |
D | VAL201 |
D | PRO202 |
D | SER206 |
D | THR207 |
D | VAL228 |
D | GLY229 |
D | ARG230 |
D | ASP254 |
D | HIS277 |
D | ALA279 |
D | MLA402 |
D | HOH516 |
D | HOH517 |
D | HOH525 |
D | HOH535 |
D | HOH542 |
D | HOH546 |
D | HOH561 |
D | HOH582 |
D | HOH591 |
D | HOH625 |
site_id | AD1 |
Number of Residues | 8 |
Details | binding site for residue MLA D 402 |
Chain | Residue |
D | GLY71 |
D | VAL72 |
D | GLY73 |
D | LEU96 |
D | ARG230 |
D | HIS277 |
D | NAP401 |
D | HOH501 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue NA D 403 |
Chain | Residue |
D | ALA191 |
D | GLU192 |
D | VAL194 |
D | ALA218 |
D | LEU219 |