5V6Q
Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with NADP and malonate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| C | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| D | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | VAL72 |
| A | THR174 |
| A | ILE200 |
| A | VAL201 |
| A | PRO202 |
| A | SER206 |
| A | THR207 |
| A | VAL228 |
| A | GLY229 |
| A | ARG230 |
| A | ASP254 |
| A | VAL100 |
| A | HIS277 |
| A | ALA279 |
| A | MLA402 |
| A | HOH512 |
| A | HOH536 |
| A | HOH552 |
| A | HOH553 |
| A | HOH561 |
| A | HOH582 |
| A | HOH587 |
| A | PHE148 |
| A | HOH589 |
| A | HOH591 |
| A | HOH624 |
| A | LEU150 |
| A | GLY151 |
| A | ARG152 |
| A | ILE153 |
| A | THR172 |
| A | ARG173 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MLA A 402 |
| Chain | Residue |
| A | GLY71 |
| A | VAL72 |
| A | GLY73 |
| A | LEU96 |
| A | ARG230 |
| A | HIS277 |
| A | SER280 |
| A | NAP401 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | ALA191 |
| A | GLU192 |
| A | VAL194 |
| A | ALA218 |
| A | LEU219 |
| A | HOH668 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | binding site for residue NAP B 401 |
| Chain | Residue |
| B | VAL72 |
| B | VAL100 |
| B | PHE148 |
| B | LEU150 |
| B | GLY151 |
| B | ARG152 |
| B | ILE153 |
| B | THR172 |
| B | ARG173 |
| B | THR174 |
| B | ILE200 |
| B | VAL201 |
| B | PRO202 |
| B | SER206 |
| B | THR207 |
| B | VAL228 |
| B | GLY229 |
| B | ARG230 |
| B | ASP254 |
| B | HIS277 |
| B | ALA279 |
| B | MLA402 |
| B | HOH504 |
| B | HOH519 |
| B | HOH523 |
| B | HOH532 |
| B | HOH540 |
| B | HOH544 |
| B | HOH561 |
| B | HOH579 |
| B | HOH590 |
| B | HOH601 |
| B | HOH604 |
| B | HOH617 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue MLA B 402 |
| Chain | Residue |
| B | GLY71 |
| B | VAL72 |
| B | GLY73 |
| B | LEU96 |
| B | ARG230 |
| B | HIS277 |
| B | NAP401 |
| B | HOH503 |
| B | HOH637 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 403 |
| Chain | Residue |
| B | ALA191 |
| B | GLU192 |
| B | VAL194 |
| B | ALA218 |
| B | LEU219 |
| site_id | AC7 |
| Number of Residues | 32 |
| Details | binding site for residue NAP C 401 |
| Chain | Residue |
| C | ARG152 |
| C | ILE153 |
| C | THR172 |
| C | ARG173 |
| C | THR174 |
| C | ILE200 |
| C | VAL201 |
| C | PRO202 |
| C | SER206 |
| C | THR207 |
| C | VAL228 |
| C | GLY229 |
| C | ARG230 |
| C | ASP254 |
| C | HIS277 |
| C | ALA279 |
| C | MLA402 |
| C | HOH505 |
| C | HOH513 |
| C | HOH525 |
| C | HOH545 |
| C | HOH553 |
| C | HOH567 |
| C | HOH583 |
| C | HOH615 |
| C | HOH620 |
| C | HOH621 |
| C | VAL72 |
| C | VAL100 |
| C | PHE148 |
| C | LEU150 |
| C | GLY151 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue MLA C 402 |
| Chain | Residue |
| C | GLY71 |
| C | VAL72 |
| C | GLY73 |
| C | LEU96 |
| C | ARG230 |
| C | HIS277 |
| C | NAP401 |
| C | HOH501 |
| C | HOH582 |
| site_id | AC9 |
| Number of Residues | 34 |
| Details | binding site for residue NAP D 401 |
| Chain | Residue |
| D | VAL72 |
| D | GLY73 |
| D | VAL100 |
| D | PHE148 |
| D | GLY149 |
| D | LEU150 |
| D | GLY151 |
| D | ARG152 |
| D | ILE153 |
| D | THR172 |
| D | ARG173 |
| D | THR174 |
| D | ILE200 |
| D | VAL201 |
| D | PRO202 |
| D | SER206 |
| D | THR207 |
| D | VAL228 |
| D | GLY229 |
| D | ARG230 |
| D | ASP254 |
| D | HIS277 |
| D | ALA279 |
| D | MLA402 |
| D | HOH516 |
| D | HOH517 |
| D | HOH525 |
| D | HOH535 |
| D | HOH542 |
| D | HOH546 |
| D | HOH561 |
| D | HOH582 |
| D | HOH591 |
| D | HOH625 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue MLA D 402 |
| Chain | Residue |
| D | GLY71 |
| D | VAL72 |
| D | GLY73 |
| D | LEU96 |
| D | ARG230 |
| D | HIS277 |
| D | NAP401 |
| D | HOH501 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 403 |
| Chain | Residue |
| D | ALA191 |
| D | GLU192 |
| D | VAL194 |
| D | ALA218 |
| D | LEU219 |
