5V6P
CryoEM structure of the ERAD-associated E3 ubiquitin-protein ligase HRD1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000836 | cellular_component | Hrd1p ubiquitin ligase complex |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0030433 | biological_process | ubiquitin-dependent ERAD pathway |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0000836 | cellular_component | Hrd1p ubiquitin ligase complex |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0030433 | biological_process | ubiquitin-dependent ERAD pathway |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | MET1-LYS8 | |
| A | GLY72-GLU84 | |
| A | ASP127-PHE147 | |
| A | LEU209-GLU271 | |
| B | MET1-LYS8 | |
| B | GLY72-GLU84 | |
| B | ASP127-PHE147 | |
| B | LEU209-GLU271 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | GLN9-LYS30 | |
| B | GLN9-LYS30 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 58 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | THR31-ASN43 | |
| A | GLU102-ARG103 | |
| A | SER170-THR183 | |
| A | PHE293-PRO296 | |
| B | THR31-ASN43 | |
| B | GLU102-ARG103 | |
| B | SER170-THR183 | |
| B | PHE293-PRO296 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | GLU44-PHE71 | |
| B | GLU44-PHE71 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | ARG85-HIS101 | |
| B | ARG85-HIS101 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | TYR104-LYS126 | |
| B | TYR104-LYS126 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | SER148-ILE169 | |
| B | SER148-ILE169 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | SER184-CYS208 | |
| B | SER184-CYS208 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | LYS272-PRO292 | |
| B | LYS272-PRO292 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:32327568 |
| Chain | Residue | Details |
| A | MET297-GLY314 | |
| B | MET297-GLY314 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 102 |
| Details | ZN_FING: RING-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00175 |
| Chain | Residue | Details |
| A | CYS349-ARG400 | |
| B | CYS349-ARG400 |
