Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5V56

2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0007166	biological_process	cell surface receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0010181	molecular_function	FMN binding
A	0016020	cellular_component	membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0007166	biological_process	cell surface receptor signaling pathway
B	0009055	molecular_function	electron transfer activity
B	0010181	molecular_function	FMN binding
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00201
Number of Residues	17
Details	FLAVODOXIN Flavodoxin signature. IVYgSTtGnTEytAEtI

Chain	Residue	Details
A	ILE1006-ILE1022

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	282
Details	Domain: {"description":"Flavodoxin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00088","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	58
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	140
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	232
Details	Domain: {"description":"FZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00090","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35658032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZI0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Lipidation: {"description":"Cholesterol aspartate ester","evidences":[{"source":"PubMed","id":"28344083","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35658032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZI0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P56726","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)