5UW6

PCY1 in Complex with Follower Peptide and Covalent Inhibitor ZPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0070012	molecular_function	oligopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0070012	molecular_function	oligopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0070012	molecular_function	oligopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0070012	molecular_function	oligopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ZPR A 801

Chain	Residue
A	PHE178
A	TYR607
A	ARG655
A	VAL656
A	HIS239
A	TYR481
A	PHE484
A	SER562
A	ASN563
A	VAL588
A	LEU602
A	TRP603

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site_id	AC2
Number of Residues	2
Details	binding site for residue CA A 802

Chain	Residue
A	ALA717
A	GLU719

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site_id	AC3
Number of Residues	3
Details	binding site for residue CA B 802

Chain	Residue
B	GLU64
B	ASP67
D	GLU61

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site_id	AC4
Number of Residues	2
Details	binding site for residue CA B 803

Chain	Residue
B	ALA717
B	GLU719

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site_id	AC5
Number of Residues	4
Details	binding site for residue CA C 802

Chain	Residue
A	GLU61
A	GLU64
C	GLU61
C	GLU64

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site_id	AC6
Number of Residues	17
Details	binding site for Di-peptide ZPR B 801 and SER B 562

Chain	Residue
B	HIS239
B	CYS259
B	TYR481
B	PHE484
B	GLY561
B	ASN563
B	GLY564
B	GLY565
B	LEU566
B	ASN585
B	CYS586
B	GLY587
B	VAL588
B	LEU602
B	TRP603
B	TYR607
B	ARG655

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site_id	AC7
Number of Residues	16
Details	binding site for Di-peptide ZPR C 801 and SER C 562

Chain	Residue
C	HIS239
C	CYS259
C	TYR481
C	PHE484
C	GLY561
C	ASN563
C	GLY564
C	GLY565
C	LEU566
C	ASN585
C	CYS586
C	GLY587
C	VAL588
C	LEU599
C	TRP603
C	TYR607

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site_id	AC8
Number of Residues	17
Details	binding site for Di-peptide ZPR D 801 and SER D 562

Chain	Residue
D	PHE178
D	HIS239
D	TYR481
D	PHE484
D	GLY561
D	ASN563
D	GLY564
D	GLY565
D	LEU566
D	ASN585
D	CYS586
D	GLY587
D	VAL588
D	LEU599
D	TRP603
D	TYR607
D	ARG655

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Functional Information from PROSITE/UniProt

site_id	PS00708
Number of Residues	31
Details	PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DfisAaeyLissgytkarrvaieGgSnGGLL

Chain	Residue	Details
A	ASP537-LEU567

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