Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| A | GLU190 |
| A | ZN402 |
| A | HOH626 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | ASN183 |
| A | ASP185 |
| A | GLU190 |
| A | CA401 |
| A | HOH523 |
| A | HOH527 |
| A | GLU177 |
| A | LYS182 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | ASP57 |
| A | ASP59 |
| A | GLN61 |
| A | HOH541 |
| A | HOH622 |
| A | HOH790 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 404 |
| Chain | Residue |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| A | ASP200 |
| A | HOH615 |
| A | HOH785 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 405 |
| Chain | Residue |
| A | HIS142 |
| A | GLU143 |
| A | HIS146 |
| A | GLU166 |
| A | ZN406 |
| A | ZN407 |
| A | HOH746 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue ZN A 406 |
| Chain | Residue |
| A | GLU166 |
| A | HIS231 |
| A | ZN405 |
| A | ZN407 |
| A | HOH520 |
| A | HOH746 |
| A | HOH799 |
| A | HOH815 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue ZN A 407 |
| Chain | Residue |
| A | GLU143 |
| A | ZN405 |
| A | ZN406 |
| A | DMF418 |
| A | HOH573 |
| A | HOH654 |
| A | HOH746 |
| A | HOH799 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 408 |
| Chain | Residue |
| A | LYS239 |
| A | ZN409 |
| A | CL410 |
| A | CL411 |
| A | HOH774 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 409 |
| Chain | Residue |
| A | HIS250 |
| A | ZN408 |
| A | CL412 |
| A | CL413 |
| A | HOH774 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 410 |
| Chain | Residue |
| A | GLY247 |
| A | ZN408 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 411 |
| Chain | Residue |
| A | SER206 |
| A | LYS239 |
| A | ZN408 |
| A | CL412 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 412 |
| Chain | Residue |
| A | ASP215 |
| A | HIS250 |
| A | ZN409 |
| A | CL411 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 413 |
| Chain | Residue |
| A | LYS45 |
| A | ARG47 |
| A | HIS250 |
| A | TYR251 |
| A | ZN409 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue DMF A 414 |
| Chain | Residue |
| A | TYR274 |
| A | ALA286 |
| A | ALA287 |
| A | HOH525 |
| A | HOH605 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue DMF A 415 |
| Chain | Residue |
| A | ASP150 |
| A | TYR151 |
| A | TRP186 |
| A | SER206 |
| A | TYR242 |
| A | HOH576 |
| A | HOH659 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue DMF A 416 |
| Chain | Residue |
| A | TYR66 |
| A | HIS216 |
| A | SER218 |
| A | TYR251 |
| A | HOH591 |
| A | HOH690 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue DMF A 417 |
| Chain | Residue |
| A | TYR27 |
| A | TYR29 |
| A | ALA56 |
| A | GLY212 |
| A | PRO214 |
| A | HOH603 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue DMF A 418 |
| Chain | Residue |
| A | ALA113 |
| A | HIS142 |
| A | GLU143 |
| A | LEU202 |
| A | ARG203 |
| A | ZN407 |
| A | HOH520 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue DMF A 419 |
| Chain | Residue |
| A | ASN21 |
| A | ARG35 |
| A | TYR75 |
| A | HOH691 |
| A | HOH719 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue DMF A 420 |
| Chain | Residue |
| A | THR299 |
| A | GLN301 |
| A | HOH517 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue DMF A 421 |
| Chain | Residue |
| A | ASP16 |
| A | GLN17 |
| A | LYS18 |
| A | TYR75 |
| A | TYR76 |
| A | LYS182 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue DMF A 422 |
| Chain | Residue |
| A | PHE114 |
| A | HOH867 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue DMF A 423 |
| Chain | Residue |
| A | ILE1 |
| A | TYR29 |
| A | LEU54 |
| A | LYS210 |
| A | GLY212 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU143 | |
| Chain | Residue | Details |
| A | HIS231 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP57 | |
| A | ASP185 | |
| A | GLU187 | |
| A | GLU190 | |
| A | TYR193 | |
| A | THR194 | |
| A | ILE197 | |
| A | ASP200 | |
| A | ASP59 | |
| A | GLN61 | |
| A | ASP138 | |
| A | HIS142 | |
| A | HIS146 | |
| A | GLU166 | |
| A | GLU177 | |
| A | ASN183 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
