Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue CA A 401 |
Chain | Residue |
A | ASP138 |
A | GLU177 |
A | ASP185 |
A | GLU187 |
A | GLU190 |
A | ZN402 |
A | HOH585 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | ASP185 |
A | GLU190 |
A | CA401 |
A | HOH521 |
A | HOH550 |
A | GLU177 |
A | ASN183 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue CA A 403 |
Chain | Residue |
A | ASP57 |
A | ASP59 |
A | GLN61 |
A | HOH576 |
A | HOH656 |
A | HOH799 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue CA A 404 |
Chain | Residue |
A | TYR193 |
A | THR194 |
A | ILE197 |
A | ASP200 |
A | HOH584 |
A | HOH778 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue ZN A 405 |
Chain | Residue |
A | HIS142 |
A | GLU143 |
A | HIS146 |
A | GLU166 |
A | ZN406 |
A | ZN407 |
A | HOH715 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue ZN A 406 |
Chain | Residue |
A | TYR157 |
A | GLU166 |
A | HIS231 |
A | ZN405 |
A | ZN407 |
A | MRD420 |
A | HOH502 |
A | HOH580 |
A | HOH699 |
A | HOH715 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue ZN A 407 |
Chain | Residue |
A | GLU143 |
A | ZN405 |
A | ZN406 |
A | MRD420 |
A | HOH549 |
A | HOH580 |
A | HOH599 |
A | HOH699 |
A | HOH715 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue ZN A 408 |
Chain | Residue |
A | ASP226 |
A | HIS231 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue ZN A 409 |
Chain | Residue |
A | LYS239 |
A | ZN410 |
A | CL413 |
A | CL414 |
A | HOH714 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue ZN A 410 |
Chain | Residue |
A | HIS250 |
A | ZN409 |
A | CL415 |
A | CL416 |
A | HOH714 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue ZN A 411 |
Chain | Residue |
A | ZN412 |
A | HOH530 |
A | HOH615 |
A | HOH785 |
A | HOH808 |
A | HOH841 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue ZN A 412 |
Chain | Residue |
A | ASP213 |
A | ZN411 |
A | HOH530 |
A | HOH615 |
A | HOH642 |
A | HOH785 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue CL A 413 |
Chain | Residue |
A | LYS239 |
A | ZN409 |
A | CL414 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue CL A 414 |
Chain | Residue |
A | LYS239 |
A | ZN409 |
A | CL413 |
A | HOH650 |
A | HOH807 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue CL A 415 |
Chain | Residue |
A | ARG47 |
A | ASP215 |
A | HIS250 |
A | ZN410 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue CL A 416 |
Chain | Residue |
A | LYS45 |
A | ARG47 |
A | HIS250 |
A | TYR251 |
A | ZN410 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue CL A 417 |
Chain | Residue |
A | ARG285 |
A | HOH821 |
A | HOH860 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue MPD A 418 |
Chain | Residue |
A | GLN290 |
A | HOH834 |
A | TYR274 |
A | GLN283 |
A | ALA286 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue MPD A 419 |
Chain | Residue |
A | ASN33 |
A | GLY36 |
A | ASN37 |
A | PHE40 |
site_id | AE2 |
Number of Residues | 10 |
Details | binding site for residue MRD A 420 |
Chain | Residue |
A | ASN112 |
A | ALA113 |
A | LEU133 |
A | HIS142 |
A | GLU143 |
A | LEU202 |
A | ZN406 |
A | ZN407 |
A | HOH502 |
A | HOH580 |
site_id | AE3 |
Number of Residues | 7 |
Details | binding site for residue MPD A 421 |
Chain | Residue |
A | SER25 |
A | TYR29 |
A | TYR211 |
A | GLY212 |
A | ASP213 |
A | HOH615 |
A | HOH785 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue MPD A 422 |
Chain | Residue |
A | GLU187 |
A | GLY199 |
A | HOH510 |
A | HOH623 |
A | HOH708 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue MRD A 423 |
Chain | Residue |
A | LEU14 |
A | ASN96 |
A | ASP191 |
A | HOH526 |
A | HOH679 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
Chain | Residue | Details |
A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU143 | |
Chain | Residue | Details |
A | HIS231 | |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP57 | |
A | ASP185 | |
A | GLU187 | |
A | GLU190 | |
A | TYR193 | |
A | THR194 | |
A | ILE197 | |
A | ASP200 | |
A | ASP59 | |
A | GLN61 | |
A | ASP138 | |
A | HIS142 | |
A | HIS146 | |
A | GLU166 | |
A | GLU177 | |
A | ASN183 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 176 |
Chain | Residue | Details |
A | HIS142 | metal ligand |
A | GLU143 | electrostatic stabiliser, metal ligand |
A | HIS146 | metal ligand |
A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
A | GLU166 | metal ligand |
A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |