Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| A | GLU190 |
| A | ZN402 |
| A | HOH585 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | ASP185 |
| A | GLU190 |
| A | CA401 |
| A | HOH521 |
| A | HOH550 |
| A | GLU177 |
| A | ASN183 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | ASP57 |
| A | ASP59 |
| A | GLN61 |
| A | HOH576 |
| A | HOH656 |
| A | HOH799 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 404 |
| Chain | Residue |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| A | ASP200 |
| A | HOH584 |
| A | HOH778 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 405 |
| Chain | Residue |
| A | HIS142 |
| A | GLU143 |
| A | HIS146 |
| A | GLU166 |
| A | ZN406 |
| A | ZN407 |
| A | HOH715 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue ZN A 406 |
| Chain | Residue |
| A | TYR157 |
| A | GLU166 |
| A | HIS231 |
| A | ZN405 |
| A | ZN407 |
| A | MRD420 |
| A | HOH502 |
| A | HOH580 |
| A | HOH699 |
| A | HOH715 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue ZN A 407 |
| Chain | Residue |
| A | GLU143 |
| A | ZN405 |
| A | ZN406 |
| A | MRD420 |
| A | HOH549 |
| A | HOH580 |
| A | HOH599 |
| A | HOH699 |
| A | HOH715 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 408 |
| Chain | Residue |
| A | ASP226 |
| A | HIS231 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 409 |
| Chain | Residue |
| A | LYS239 |
| A | ZN410 |
| A | CL413 |
| A | CL414 |
| A | HOH714 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 410 |
| Chain | Residue |
| A | HIS250 |
| A | ZN409 |
| A | CL415 |
| A | CL416 |
| A | HOH714 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 411 |
| Chain | Residue |
| A | ZN412 |
| A | HOH530 |
| A | HOH615 |
| A | HOH785 |
| A | HOH808 |
| A | HOH841 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 412 |
| Chain | Residue |
| A | ASP213 |
| A | ZN411 |
| A | HOH530 |
| A | HOH615 |
| A | HOH642 |
| A | HOH785 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 413 |
| Chain | Residue |
| A | LYS239 |
| A | ZN409 |
| A | CL414 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 414 |
| Chain | Residue |
| A | LYS239 |
| A | ZN409 |
| A | CL413 |
| A | HOH650 |
| A | HOH807 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 415 |
| Chain | Residue |
| A | ARG47 |
| A | ASP215 |
| A | HIS250 |
| A | ZN410 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 416 |
| Chain | Residue |
| A | LYS45 |
| A | ARG47 |
| A | HIS250 |
| A | TYR251 |
| A | ZN410 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 417 |
| Chain | Residue |
| A | ARG285 |
| A | HOH821 |
| A | HOH860 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MPD A 418 |
| Chain | Residue |
| A | GLN290 |
| A | HOH834 |
| A | TYR274 |
| A | GLN283 |
| A | ALA286 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 419 |
| Chain | Residue |
| A | ASN33 |
| A | GLY36 |
| A | ASN37 |
| A | PHE40 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue MRD A 420 |
| Chain | Residue |
| A | ASN112 |
| A | ALA113 |
| A | LEU133 |
| A | HIS142 |
| A | GLU143 |
| A | LEU202 |
| A | ZN406 |
| A | ZN407 |
| A | HOH502 |
| A | HOH580 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue MPD A 421 |
| Chain | Residue |
| A | SER25 |
| A | TYR29 |
| A | TYR211 |
| A | GLY212 |
| A | ASP213 |
| A | HOH615 |
| A | HOH785 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue MPD A 422 |
| Chain | Residue |
| A | GLU187 |
| A | GLY199 |
| A | HOH510 |
| A | HOH623 |
| A | HOH708 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue MRD A 423 |
| Chain | Residue |
| A | LEU14 |
| A | ASN96 |
| A | ASP191 |
| A | HOH526 |
| A | HOH679 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU143 | |
| Chain | Residue | Details |
| A | HIS231 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP57 | |
| A | ASP185 | |
| A | GLU187 | |
| A | GLU190 | |
| A | TYR193 | |
| A | THR194 | |
| A | ILE197 | |
| A | ASP200 | |
| A | ASP59 | |
| A | GLN61 | |
| A | ASP138 | |
| A | HIS142 | |
| A | HIS146 | |
| A | GLU166 | |
| A | GLU177 | |
| A | ASN183 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
