Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue CA A 401 |
Chain | Residue |
A | ASP138 |
A | GLU177 |
A | ASP185 |
A | GLU187 |
A | GLU190 |
A | ZN402 |
A | HOH584 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | ASP185 |
A | GLU190 |
A | CA401 |
A | HOH525 |
A | HOH538 |
A | GLU177 |
A | ASN183 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue CA A 403 |
Chain | Residue |
A | ASP57 |
A | ASP59 |
A | GLN61 |
A | HOH522 |
A | HOH563 |
A | HOH718 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue CA A 404 |
Chain | Residue |
A | TYR193 |
A | THR194 |
A | ILE197 |
A | ASP200 |
A | HOH559 |
A | HOH686 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue ZN A 405 |
Chain | Residue |
A | HIS142 |
A | HIS146 |
A | GLU166 |
A | ZN406 |
A | HOH620 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue ZN A 406 |
Chain | Residue |
A | GLU143 |
A | ZN405 |
A | MRD416 |
A | HOH535 |
A | HOH620 |
A | HOH633 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN A 407 |
Chain | Residue |
A | ASP226 |
A | HIS231 |
A | HOH721 |
A | HOH736 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue ZN A 408 |
Chain | Residue |
A | LYS239 |
A | ZN409 |
A | CL411 |
A | CL412 |
A | HOH636 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue ZN A 409 |
Chain | Residue |
A | HIS250 |
A | ZN408 |
A | CL413 |
A | CL414 |
A | HOH636 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue ZN A 410 |
Chain | Residue |
A | ASP213 |
A | HOH515 |
A | HOH604 |
A | HOH614 |
A | HOH666 |
A | HOH744 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue CL A 411 |
Chain | Residue |
A | LYS239 |
A | ZN408 |
A | CL412 |
A | HOH636 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue CL A 412 |
Chain | Residue |
A | LYS239 |
A | ZN408 |
A | CL411 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue CL A 413 |
Chain | Residue |
A | ARG47 |
A | ASP215 |
A | HIS250 |
A | ZN409 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue CL A 414 |
Chain | Residue |
A | LYS45 |
A | ARG47 |
A | HIS250 |
A | TYR251 |
A | ZN409 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue MRD A 415 |
Chain | Residue |
A | TYR274 |
A | GLN283 |
A | ALA286 |
site_id | AD7 |
Number of Residues | 9 |
Details | binding site for residue MRD A 416 |
Chain | Residue |
A | ASN112 |
A | ALA113 |
A | LEU133 |
A | HIS142 |
A | GLU143 |
A | LEU202 |
A | ARG203 |
A | ZN406 |
A | HOH625 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue MPD A 417 |
Chain | Residue |
A | SER25 |
A | TYR29 |
A | GLY212 |
A | ASP213 |
A | HOH548 |
A | HOH604 |
A | HOH666 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue DMS A 418 |
Chain | Residue |
A | HIS216 |
A | HOH747 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
Chain | Residue | Details |
A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU143 | |
Chain | Residue | Details |
A | HIS231 | |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP57 | |
A | ASP185 | |
A | GLU187 | |
A | GLU190 | |
A | TYR193 | |
A | THR194 | |
A | ILE197 | |
A | ASP200 | |
A | ASP59 | |
A | GLN61 | |
A | ASP138 | |
A | HIS142 | |
A | HIS146 | |
A | GLU166 | |
A | GLU177 | |
A | ASN183 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 176 |
Chain | Residue | Details |
A | HIS142 | metal ligand |
A | GLU143 | electrostatic stabiliser, metal ligand |
A | HIS146 | metal ligand |
A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
A | GLU166 | metal ligand |
A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |