5UU3

Insulin with proline analog DfP at position B28 in the R6 state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
M	0005179	molecular_function	hormone activity
M	0005576	cellular_component	extracellular region
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
O	0005179	molecular_function	hormone activity
O	0005576	cellular_component	extracellular region
P	0005179	molecular_function	hormone activity
P	0005576	cellular_component	extracellular region
Q	0005179	molecular_function	hormone activity
Q	0005576	cellular_component	extracellular region
R	0005179	molecular_function	hormone activity
R	0005576	cellular_component	extracellular region
S	0005179	molecular_function	hormone activity
S	0005576	cellular_component	extracellular region
T	0005179	molecular_function	hormone activity
T	0005576	cellular_component	extracellular region
U	0005179	molecular_function	hormone activity
U	0005576	cellular_component	extracellular region
V	0005179	molecular_function	hormone activity
V	0005576	cellular_component	extracellular region
W	0005179	molecular_function	hormone activity
W	0005576	cellular_component	extracellular region
X	0005179	molecular_function	hormone activity
X	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue IPH A 101

Chain	Residue
A	CYS6
A	CYS11

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS10
F	HIS10
F	CL101
J	HIS10

---

site_id	AC3
Number of Residues	7
Details	binding site for residue IPH C 101

Chain	Residue
C	CYS11
C	LEU16
D	LEU11
L	HIS5
C	CYS6
C	SER9
C	ILE10

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 101

Chain	Residue
D	HIS10
D	CL102
H	HIS10
L	HIS10

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CL D 102

Chain	Residue
D	HIS10
D	ZN101
H	HIS10
L	HIS10

---

site_id	AC6
Number of Residues	4
Details	binding site for residue IPH E 101

Chain	Residue
E	CYS6
E	CYS11
F	LEU11
J	HIS5

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CL F 101

Chain	Residue
B	HIS10
B	ZN301
F	HIS10
J	HIS10

---

site_id	AC8
Number of Residues	4
Details	binding site for residue IPH G 101

Chain	Residue
D	HIS5
G	CYS6
G	CYS11
H	LEU11

---

site_id	AC9
Number of Residues	5
Details	binding site for residue IPH I 101

Chain	Residue
B	HIS5
I	CYS6
I	ILE10
I	CYS11
J	LEU11

---

site_id	AD1
Number of Residues	6
Details	binding site for residue IPH K 101

Chain	Residue
H	HIS5
K	CYS6
K	SER9
K	ILE10
K	CYS11
L	LEU11

---

site_id	AD2
Number of Residues	5
Details	binding site for residue IPH M 101

Chain	Residue
M	CYS6
M	ILE10
M	CYS11
N	LEU11
R	HIS5

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN N 301

Chain	Residue
N	HIS10
N	CL302
R	HIS10
V	HIS10

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL N 302

Chain	Residue
N	HIS10
N	ZN301
R	HIS10
V	HIS10

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN P 101

Chain	Residue
P	HIS10
P	CL102
T	HIS10
X	HIS10

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CL P 102

Chain	Residue
P	HIS10
P	ZN101
T	HIS10
X	HIS10

---

site_id	AD7
Number of Residues	2
Details	binding site for residue IPH Q 101

Chain	Residue
Q	CYS6
Q	CYS11

---

site_id	AD8
Number of Residues	4
Details	binding site for residue IPH S 101

Chain	Residue
P	HIS5
S	CYS6
S	CYS11
T	LEU11

---

site_id	AD9
Number of Residues	6
Details	binding site for residue IPH U 101

Chain	Residue
N	HIS5
U	CYS6
U	SER9
U	ILE10
U	CYS11
V	LEU11

---

site_id	AE1
Number of Residues	5
Details	binding site for residue IPH W 101

Chain	Residue
T	HIS5
W	CYS6
W	SER9
W	CYS11
X	LEU11

---

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Peptide: {"description":"Insulin A chain","featureId":"PRO_0000015821"}

Chain

Residue

Details

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