5USF
Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004831 | molecular_function | tyrosine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006437 | biological_process | tyrosyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004831 | molecular_function | tyrosine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006437 | biological_process | tyrosyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue YSA A 701 |
| Chain | Residue |
| A | TYR36 |
| A | TYR163 |
| A | GLN167 |
| A | ASP170 |
| A | LEU181 |
| A | GLY182 |
| A | ASP184 |
| A | GLN185 |
| A | HIS210 |
| A | HIS211 |
| A | MET212 |
| A | ASP37 |
| A | LEU213 |
| A | MET223 |
| A | HOH821 |
| A | GLY38 |
| A | PHE39 |
| A | GLU40 |
| A | ALA48 |
| A | GLN49 |
| A | TRP70 |
| A | ILE148 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue YSA B 701 |
| Chain | Residue |
| B | TYR36 |
| B | ASP37 |
| B | GLY38 |
| B | PHE39 |
| B | GLU40 |
| B | ALA48 |
| B | GLN49 |
| B | TRP70 |
| B | ILE148 |
| B | TYR163 |
| B | GLN167 |
| B | ASP170 |
| B | LEU181 |
| B | GLY182 |
| B | ASP184 |
| B | GLN185 |
| B | HIS210 |
| B | HIS211 |
| B | MET212 |
| B | LEU213 |
| B | MET223 |
Functional Information from PROSITE/UniProt
| site_id | PS00191 |
| Number of Residues | 8 |
| Details | CYTOCHROME_B5_1 Cytochrome b5 family, heme-binding domain signature. FIAAHPGG |
| Chain | Residue | Details |
| A | PHE401-GLY408 |
