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5US8

2.15 Angstrom Resolution Crystal Structure of Argininosuccinate Synthase from Bordetella pertussis

Functional Information from GO Data
ChainGOidnamespacecontents
A0000050biological_processurea cycle
A0000053biological_processargininosuccinate metabolic process
A0004055molecular_functionargininosuccinate synthase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006526biological_processL-arginine biosynthetic process
A0016874molecular_functionligase activity
A0042803molecular_functionprotein homodimerization activity
B0000050biological_processurea cycle
B0000053biological_processargininosuccinate metabolic process
B0004055molecular_functionargininosuccinate synthase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0006526biological_processL-arginine biosynthetic process
B0016874molecular_functionligase activity
B0042803molecular_functionprotein homodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue EPE A 501
ChainResidue
ATYR254
AALA255
AASP256
AHOH728

site_idAC2
Number of Residues2
Detailsbinding site for residue PGE A 502
ChainResidue
AGLY180
AARG270

site_idAC3
Number of Residues3
Detailsbinding site for residue EPE B 501
ChainResidue
BTYR254
BALA255
BASP256

site_idAC4
Number of Residues8
Detailsbinding site for residue EPE B 502
ChainResidue
BGLY21
BLEU22
BGLN47
BASP49
BGLU50
BARG169
BTYR183
BSER186

site_idAC5
Number of Residues10
Detailsbinding site for residue ADN B 503
ChainResidue
AGLU318
AGLU322
AARG325
ALYS326
BARG321
BGLU322
BARG325
BLYS326
BHOH601
BHOH678

site_idAC6
Number of Residues1
Detailsbinding site for residue SO4 B 504
ChainResidue
BHOH694

Functional Information from PROSITE/UniProt
site_idPS00564
Number of Residues9
DetailsARGININOSUCCIN_SYN_1 Argininosuccinate synthase signature 1. AFSGGLDTS
ChainResidueDetails
AALA17-SER25

site_idPS00565
Number of Residues12
DetailsARGININOSUCCIN_SYN_2 Argininosuccinate synthase signature 2. GsTfKGNDieRF
ChainResidueDetails
AGLY129-PHE140

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00581
ChainResidueDetails
AALA17
AASP194
ATHR201
AGLU203
AGLU280
BALA17
BALA43
BTYR99
BGLY129
BTHR131
BASN135
AALA43
BASP136
BARG139
BSER192
BASP194
BTHR201
BGLU203
BGLU280
ATYR99
AGLY129
ATHR131
AASN135
AASP136
AARG139
ASER192

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PDB entries from 2024-11-06

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