5URA
Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007399 | biological_process | nervous system development |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0050673 | biological_process | epithelial cell proliferation |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007399 | biological_process | nervous system development |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0050673 | biological_process | epithelial cell proliferation |
| C | 0005504 | molecular_function | fatty acid binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0007399 | biological_process | nervous system development |
| C | 0008285 | biological_process | negative regulation of cell population proliferation |
| C | 0008289 | molecular_function | lipid binding |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0050673 | biological_process | epithelial cell proliferation |
| D | 0005504 | molecular_function | fatty acid binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0007399 | biological_process | nervous system development |
| D | 0008285 | biological_process | negative regulation of cell population proliferation |
| D | 0008289 | molecular_function | lipid binding |
| D | 0015908 | biological_process | fatty acid transport |
| D | 0050673 | biological_process | epithelial cell proliferation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 8KS A 201 |
| Chain | Residue |
| A | PHE17 |
| A | MET116 |
| A | LEU118 |
| A | ARG127 |
| A | TYR129 |
| A | HOH312 |
| A | HOH327 |
| A | HOH432 |
| A | MET21 |
| A | GLY34 |
| A | THR37 |
| A | PRO39 |
| A | THR54 |
| A | SER56 |
| A | ASP77 |
| A | PHE105 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | PHE28 |
| A | ARG31 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | THR37 |
| A | LYS38 |
| A | SER56 |
| A | THR57 |
| A | HOH311 |
| A | HOH407 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue 8KS B 201 |
| Chain | Residue |
| B | PHE17 |
| B | MET21 |
| B | GLY34 |
| B | THR37 |
| B | PRO39 |
| B | VAL41 |
| B | THR54 |
| B | SER56 |
| B | LYS59 |
| B | ALA76 |
| B | ASP77 |
| B | PHE105 |
| B | MET116 |
| B | LEU118 |
| B | ARG127 |
| B | TYR129 |
| B | HOH322 |
| B | HOH340 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | LYS22 |
| B | PHE28 |
| B | ARG31 |
| B | HOH305 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| B | SER14 |
| B | ASN16 |
| B | HOH302 |
| B | HOH335 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue 8KS C 201 |
| Chain | Residue |
| C | PHE17 |
| C | MET21 |
| C | GLY34 |
| C | PRO39 |
| C | VAL41 |
| C | THR54 |
| C | SER56 |
| C | LYS59 |
| C | ALA76 |
| C | ASP77 |
| C | MET116 |
| C | LEU118 |
| C | ARG127 |
| C | TYR129 |
| C | HOH329 |
| C | HOH359 |
| C | HOH363 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | ARG31 |
| C | HOH308 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 203 |
| Chain | Residue |
| C | SER14 |
| C | GLN15 |
| C | ASN16 |
| C | HOH313 |
| C | HOH327 |
| C | HOH349 |
| site_id | AD1 |
| Number of Residues | 19 |
| Details | binding site for residue 8KS D 201 |
| Chain | Residue |
| D | PHE17 |
| D | MET21 |
| D | THR30 |
| D | GLY34 |
| D | THR37 |
| D | PRO39 |
| D | VAL41 |
| D | THR54 |
| D | SER56 |
| D | ALA76 |
| D | ASP77 |
| D | PHE105 |
| D | MET116 |
| D | LEU118 |
| D | ARG127 |
| D | TYR129 |
| D | HOH316 |
| D | HOH327 |
| D | HOH416 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| D | ARG31 |
| D | HOH302 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 203 |
| Chain | Residue |
| D | THR57 |
| D | THR37 |
| D | LYS38 |
| D | SER56 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. ATWkLtnSqNFDeYMKAL |
| Chain | Residue | Details |
| A | ALA7-LEU24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG127 | |
| B | ARG127 | |
| C | ARG127 | |
| D | ARG127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylvaline => ECO:0000250|UniProtKB:Q09139 |
| Chain | Residue | Details |
| A | VAL2 | |
| B | VAL2 | |
| C | VAL2 | |
| D | VAL2 |
