Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5UR9

Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001972	molecular_function	retinoic acid binding
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0010829	biological_process	negative regulation of glucose transmembrane transport
A	0014069	cellular_component	postsynaptic density
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0030667	cellular_component	secretory granule membrane
A	0031392	biological_process	regulation of prostaglandin biosynthetic process
A	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
A	0035578	cellular_component	azurophil granule lumen
A	0042593	biological_process	glucose homeostasis
A	0042802	molecular_function	identical protein binding
A	0045202	cellular_component	synapse
A	0051930	biological_process	regulation of sensory perception of pain
A	0070062	cellular_component	extracellular exosome
A	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1990379	biological_process	lipid transport across blood-brain barrier
B	0001972	molecular_function	retinoic acid binding
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006006	biological_process	glucose metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0010829	biological_process	negative regulation of glucose transmembrane transport
B	0014069	cellular_component	postsynaptic density
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0030667	cellular_component	secretory granule membrane
B	0031392	biological_process	regulation of prostaglandin biosynthetic process
B	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
B	0035578	cellular_component	azurophil granule lumen
B	0042593	biological_process	glucose homeostasis
B	0042802	molecular_function	identical protein binding
B	0045202	cellular_component	synapse
B	0051930	biological_process	regulation of sensory perception of pain
B	0070062	cellular_component	extracellular exosome
B	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	1990379	biological_process	lipid transport across blood-brain barrier
C	0001972	molecular_function	retinoic acid binding
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006629	biological_process	lipid metabolic process
C	0006656	biological_process	phosphatidylcholine biosynthetic process
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0008544	biological_process	epidermis development
C	0010829	biological_process	negative regulation of glucose transmembrane transport
C	0014069	cellular_component	postsynaptic density
C	0015908	biological_process	fatty acid transport
C	0015909	biological_process	long-chain fatty acid transport
C	0030667	cellular_component	secretory granule membrane
C	0031392	biological_process	regulation of prostaglandin biosynthetic process
C	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
C	0035578	cellular_component	azurophil granule lumen
C	0042593	biological_process	glucose homeostasis
C	0042802	molecular_function	identical protein binding
C	0045202	cellular_component	synapse
C	0051930	biological_process	regulation of sensory perception of pain
C	0070062	cellular_component	extracellular exosome
C	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	1990379	biological_process	lipid transport across blood-brain barrier
D	0001972	molecular_function	retinoic acid binding
D	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006006	biological_process	glucose metabolic process
D	0006629	biological_process	lipid metabolic process
D	0006656	biological_process	phosphatidylcholine biosynthetic process
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0008544	biological_process	epidermis development
D	0010829	biological_process	negative regulation of glucose transmembrane transport
D	0014069	cellular_component	postsynaptic density
D	0015908	biological_process	fatty acid transport
D	0015909	biological_process	long-chain fatty acid transport
D	0030667	cellular_component	secretory granule membrane
D	0031392	biological_process	regulation of prostaglandin biosynthetic process
D	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
D	0035578	cellular_component	azurophil granule lumen
D	0042593	biological_process	glucose homeostasis
D	0042802	molecular_function	identical protein binding
D	0045202	cellular_component	synapse
D	0051930	biological_process	regulation of sensory perception of pain
D	0070062	cellular_component	extracellular exosome
D	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
D	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	1990379	biological_process	lipid transport across blood-brain barrier
E	0001972	molecular_function	retinoic acid binding
E	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
E	0005504	molecular_function	fatty acid binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006006	biological_process	glucose metabolic process
E	0006629	biological_process	lipid metabolic process
E	0006656	biological_process	phosphatidylcholine biosynthetic process
E	0006869	biological_process	lipid transport
E	0008289	molecular_function	lipid binding
E	0008544	biological_process	epidermis development
E	0010829	biological_process	negative regulation of glucose transmembrane transport
E	0014069	cellular_component	postsynaptic density
E	0015908	biological_process	fatty acid transport
E	0015909	biological_process	long-chain fatty acid transport
E	0030667	cellular_component	secretory granule membrane
E	0031392	biological_process	regulation of prostaglandin biosynthetic process
E	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
E	0035578	cellular_component	azurophil granule lumen
E	0042593	biological_process	glucose homeostasis
E	0042802	molecular_function	identical protein binding
E	0045202	cellular_component	synapse
E	0051930	biological_process	regulation of sensory perception of pain
E	0070062	cellular_component	extracellular exosome
E	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
E	0120162	biological_process	positive regulation of cold-induced thermogenesis
E	1990379	biological_process	lipid transport across blood-brain barrier
F	0001972	molecular_function	retinoic acid binding
F	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
F	0005504	molecular_function	fatty acid binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006006	biological_process	glucose metabolic process
F	0006629	biological_process	lipid metabolic process
F	0006656	biological_process	phosphatidylcholine biosynthetic process
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0008544	biological_process	epidermis development
F	0010829	biological_process	negative regulation of glucose transmembrane transport
F	0014069	cellular_component	postsynaptic density
F	0015908	biological_process	fatty acid transport
F	0015909	biological_process	long-chain fatty acid transport
F	0030667	cellular_component	secretory granule membrane
F	0031392	biological_process	regulation of prostaglandin biosynthetic process
F	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
F	0035578	cellular_component	azurophil granule lumen
F	0042593	biological_process	glucose homeostasis
F	0042802	molecular_function	identical protein binding
F	0045202	cellular_component	synapse
F	0051930	biological_process	regulation of sensory perception of pain
F	0070062	cellular_component	extracellular exosome
F	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
F	0120162	biological_process	positive regulation of cold-induced thermogenesis
F	1990379	biological_process	lipid transport across blood-brain barrier
G	0001972	molecular_function	retinoic acid binding
G	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
G	0005504	molecular_function	fatty acid binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006006	biological_process	glucose metabolic process
G	0006629	biological_process	lipid metabolic process
G	0006656	biological_process	phosphatidylcholine biosynthetic process
G	0006869	biological_process	lipid transport
G	0008289	molecular_function	lipid binding
G	0008544	biological_process	epidermis development
G	0010829	biological_process	negative regulation of glucose transmembrane transport
G	0014069	cellular_component	postsynaptic density
G	0015908	biological_process	fatty acid transport
G	0015909	biological_process	long-chain fatty acid transport
G	0030667	cellular_component	secretory granule membrane
G	0031392	biological_process	regulation of prostaglandin biosynthetic process
G	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
G	0035578	cellular_component	azurophil granule lumen
G	0042593	biological_process	glucose homeostasis
G	0042802	molecular_function	identical protein binding
G	0045202	cellular_component	synapse
G	0051930	biological_process	regulation of sensory perception of pain
G	0070062	cellular_component	extracellular exosome
G	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
G	0120162	biological_process	positive regulation of cold-induced thermogenesis
G	1990379	biological_process	lipid transport across blood-brain barrier
H	0001972	molecular_function	retinoic acid binding
H	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
H	0005504	molecular_function	fatty acid binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006006	biological_process	glucose metabolic process
H	0006629	biological_process	lipid metabolic process
H	0006656	biological_process	phosphatidylcholine biosynthetic process
H	0006869	biological_process	lipid transport
H	0008289	molecular_function	lipid binding
H	0008544	biological_process	epidermis development
H	0010829	biological_process	negative regulation of glucose transmembrane transport
H	0014069	cellular_component	postsynaptic density
H	0015908	biological_process	fatty acid transport
H	0015909	biological_process	long-chain fatty acid transport
H	0030667	cellular_component	secretory granule membrane
H	0031392	biological_process	regulation of prostaglandin biosynthetic process
H	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
H	0035578	cellular_component	azurophil granule lumen
H	0042593	biological_process	glucose homeostasis
H	0042802	molecular_function	identical protein binding
H	0045202	cellular_component	synapse
H	0051930	biological_process	regulation of sensory perception of pain
H	0070062	cellular_component	extracellular exosome
H	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
H	0120162	biological_process	positive regulation of cold-induced thermogenesis
H	1990379	biological_process	lipid transport across blood-brain barrier

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 8KS A 201

Chain	Residue
A	THR56
A	LYS61
A	THR62
A	THR63
A	ALA78
F	ARG12
F	VAL14
H	LYS55
H	THR62

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG12
A	GLU135
E	LYS24
E	ARG33

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 203

Chain	Residue
A	ILE30
A	ARG33

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 204

Chain	Residue
A	SER16
A	LYS17
A	GLY18
A	PHE19
A	ASP20

site_id	AC5
Number of Residues	7
Details	binding site for residue MYR A 205

Chain	Residue
A	PHE19
A	MET23
A	GLY36
A	CYS120
A	ARG129
A	TYR131
A	HOH326

site_id	AC6
Number of Residues	14
Details	binding site for residue 8KS B 201

Chain	Residue
B	LEU32
B	MET35
B	ALA39
B	THR56
B	SER58
B	LYS61
B	THR62
B	THR63
B	ALA78
B	MYR204
B	HOH327
E	ARG12
G	LYS55
G	THR62

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 B 202

Chain	Residue
B	SER16
B	LYS17
B	GLY18
B	PHE19
B	ASP20

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 B 203

Chain	Residue
B	LYS24
B	ARG33

site_id	AC9
Number of Residues	7
Details	binding site for residue MYR B 204

Chain	Residue
B	PHE19
B	MET23
B	ASP79
B	ARG129
B	TYR131
B	8KS201
B	HOH311

site_id	AD1
Number of Residues	9
Details	binding site for residue 8KS C 201

Chain	Residue
C	LEU32
C	THR56
C	SER58
C	LYS61
C	THR62
C	ALA78
E	LYS55
E	THR62
G	ARG12

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 C 202

Chain	Residue
C	SER16
C	LYS17
C	GLY18
C	PHE19
C	ASP20

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 C 203

Chain	Residue
C	ARG10
C	ARG12
C	VAL134
H	LYS24
H	ARG33

site_id	AD4
Number of Residues	3
Details	binding site for residue MYR C 204

Chain	Residue
C	ARG129
C	TYR131
C	HOH305

site_id	AD5
Number of Residues	14
Details	binding site for residue 8KS D 201

Chain	Residue
D	LEU32
D	ALA39
D	THR56
D	SER58
D	LYS61
D	THR62
D	ALA78
D	ASP79
D	MYR204
D	HOH301
F	LYS55
F	THR62
H	ARG12
H	1PE203

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 D 202

Chain	Residue
D	SER16
D	LYS17
D	GLY18
D	PHE19
D	ASP20

site_id	AD7
Number of Residues	7
Details	binding site for residue SO4 D 203

Chain	Residue
D	SER58
D	THR59
G	ILE30
G	LYS34
D	ARG10
D	ASP42
D	GLU57

site_id	AD8
Number of Residues	5
Details	binding site for residue MYR D 204

Chain	Residue
D	ASP79
D	ARG129
D	TYR131
D	8KS201
D	HOH315

site_id	AD9
Number of Residues	11
Details	binding site for residue 8KS E 201

Chain	Residue
E	PHE19
E	GLY36
E	ALA39
E	PRO41
E	THR56
E	SER58
E	LYS61
E	ILE107
E	CYS120
E	ARG129
E	TYR131

site_id	AE1
Number of Residues	6
Details	binding site for residue SO4 E 202

Chain	Residue
E	SER16
E	LYS17
E	GLY18
E	PHE19
E	ASP20
E	GLU21

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 E 203

Chain	Residue
E	PHE89
E	THR90
E	ASP91

site_id	AE3
Number of Residues	10
Details	binding site for residue 8KS F 201

Chain	Residue
F	MET23
F	MET35
F	GLY36
F	ALA39
F	PRO41
F	THR56
F	SER58
F	CYS120
F	ARG129
F	TYR131

site_id	AE4
Number of Residues	4
Details	binding site for residue SO4 F 202

Chain	Residue
B	ARG12
B	VAL134
F	LYS24
F	ARG33

site_id	AE5
Number of Residues	9
Details	binding site for residue 8KS G 201

Chain	Residue
G	PHE19
G	GLY36
G	ALA39
G	PRO41
G	THR56
G	SER58
G	CYS120
G	ARG129
G	TYR131

site_id	AE6
Number of Residues	6
Details	binding site for residue SO4 G 202

Chain	Residue
G	SER16
G	LYS17
G	GLY18
G	PHE19
G	ASP20
G	HOH320

site_id	AE7
Number of Residues	10
Details	binding site for residue 1PE G 204

Chain	Residue
E	LYS40
E	ASP42
E	THR59
G	LYS40
G	GLU57
G	SER58
G	THR59
G	HOH301
G	HOH326
G	HOH333

site_id	AE8
Number of Residues	11
Details	binding site for residue 8KS H 201

Chain	Residue
H	PHE19
H	LEU32
H	MET35
H	GLY36
H	ALA39
H	PRO41
H	THR56
H	CYS120
H	ARG129
H	TYR131
H	HOH301

site_id	AE9
Number of Residues	6
Details	binding site for residue SO4 H 202

Chain	Residue
H	SER16
H	LYS17
H	GLY18
H	PHE19
H	ASP20
H	GLU21

site_id	AF1
Number of Residues	11
Details	binding site for residue 1PE H 203

Chain	Residue
D	8KS201
D	HOH301
F	ARG12
F	LYS40
F	ASP42
F	GLU57
H	ARG12
H	LYS40
H	ASP42
H	GLU57
H	THR59

site_id	AF2
Number of Residues	13
Details	binding site for Di-peptide SO4 G 203 and ARG G 33

Chain	Residue
D	ARG10
D	ARG12
D	GLU135
G	ASP20
G	LYS24
G	VAL28
G	GLY29
G	ILE30
G	ALA31
G	LEU32
G	LYS34
G	MET35
G	ALA37

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GRWrLvdSkGFDeYMKEL

Chain	Residue	Details
A	GLY9-LEU26

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:24531463, ECO:0007744\|PDB:4AZR

Chain	Residue	Details
F	ARG109
F	TYR131
G	CYS43
G	ARG109
G	TYR131
H	CYS43
H	ARG109
H	TYR131
E	TYR131
F	CYS43
A	CYS43
A	ARG109
A	TYR131
B	CYS43
B	ARG109
B	TYR131
C	CYS43
C	ARG109
C	TYR131
D	CYS43
D	ARG109
D	TYR131
E	CYS43
E	ARG109

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:24692551, ECO:0007744\|PDB:4LKT

Chain	Residue	Details
E	ARG129
F	ARG129
G	ARG129
H	ARG129
A	ARG129
B	ARG129
C	ARG129
D	ARG129

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:12665801, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS17
B	LYS17
C	LYS17
D	LYS17
E	LYS17
F	LYS17
G	LYS17
H	LYS17

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
A	TYR131
B	TYR131
C	TYR131
D	TYR131
E	TYR131
F	TYR131
G	TYR131
H	TYR131

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)