5UR2

Crystal structure of proline utilization A (PutA) from Bdellovibrio bacteriovorus inactivated by N-propargylglycine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
A	0004657	molecular_function	proline dehydrogenase activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006562	biological_process	proline catabolic process
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010133	biological_process	proline catabolic process to glutamate
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
B	0004657	molecular_function	proline dehydrogenase activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006562	biological_process	proline catabolic process
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010133	biological_process	proline catabolic process to glutamate
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
C	0004657	molecular_function	proline dehydrogenase activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006562	biological_process	proline catabolic process
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0010133	biological_process	proline catabolic process to glutamate
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
D	0004657	molecular_function	proline dehydrogenase activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006562	biological_process	proline catabolic process
D	0009898	cellular_component	cytoplasmic side of plasma membrane
D	0010133	biological_process	proline catabolic process to glutamate
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue P5F A 1001

Chain	Residue
A	LYS196
A	GLY302
A	ALA303
A	TRP305
A	TYR322
A	THR323
A	ASN324
A	LYS325
A	SER328
A	ALA351
A	SER352
A	ASP237
A	HIS353
A	ASN354
A	GLN378
A	MET379
A	LEU380
A	TYR401
A	GLU420
A	GLU425
A	TRP427
A	HOH1302
A	MET238
A	HOH1309
A	HOH1341
A	VAL269
A	GLN271
A	TYR273
A	ARG298
A	VAL300
A	LYS301

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site_id	AC2
Number of Residues	34
Details	binding site for Di-peptide P5F B 1001 and LYS B 196

Chain	Residue
B	TYR156
B	VAL195
B	MET197
B	THR198
B	ALA199
B	ASP237
B	MET238
B	VAL269
B	GLN271
B	TYR273
B	ARG298
B	VAL300
B	LYS301
B	GLY302
B	ALA303
B	TRP305
B	TYR322
B	THR323
B	ASN324
B	LYS325
B	SER328
B	ALA351
B	SER352
B	HIS353
B	ASN354
B	GLN378
B	MET379
B	LEU380
B	TYR401
B	GLU420
B	GLU425
B	SER426
B	TRP427
B	HOH1220

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site_id	AC3
Number of Residues	33
Details	binding site for Di-peptide P5F C 1001 and LYS C 196

Chain	Residue
C	TYR156
C	VAL195
C	MET197
C	THR198
C	ALA199
C	ASP237
C	MET238
C	GLU239
C	VAL269
C	GLN271
C	TYR273
C	VAL300
C	LYS301
C	GLY302
C	ALA303
C	TYR304
C	TRP305
C	TYR322
C	THR323
C	ASN324
C	LYS325
C	SER328
C	SER352
C	HIS353
C	ASN354
C	GLN378
C	MET379
C	LEU380
C	TYR401
C	GLU420
C	GLU425
C	TRP427
C	HOH1257

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site_id	AC4
Number of Residues	34
Details	binding site for Di-peptide P5F D 1001 and LYS D 196

Chain	Residue
D	VAL195
D	MET197
D	THR198
D	ALA199
D	ASP237
D	MET238
D	GLU239
D	VAL269
D	GLN271
D	TYR273
D	VAL300
D	LYS301
D	GLY302
D	ALA303
D	TYR304
D	TRP305
D	TYR322
D	THR323
D	ASN324
D	LYS325
D	SER328
D	SER352
D	HIS353
D	ASN354
D	GLN378
D	MET379
D	LEU380
D	TYR401
D	GLU420
D	SER426
D	TRP427
D	HOH1117
D	HOH1220
D	TYR156

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Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FgFSGQKCSAAS

Chain	Residue	Details
A	PHE771-SER782

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site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. IEMGGKNA

Chain	Residue	Details
A	ILE743-ALA750

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