5UR0
Crystallographic structure of glyceraldehyde-3-phosphate dehydrogenase from Naegleria gruberi
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | ASN7 |
| A | MET36 |
| A | ARG78 |
| A | SER96 |
| A | THR97 |
| A | GLY98 |
| A | SER120 |
| A | ALA121 |
| A | CSD149 |
| A | OCS149 |
| A | ALA180 |
| A | GLY8 |
| A | ASN314 |
| A | TYR318 |
| A | HOH519 |
| A | HOH521 |
| A | HOH523 |
| A | HOH530 |
| A | HOH551 |
| A | HOH552 |
| A | HOH558 |
| A | HOH602 |
| A | GLY10 |
| A | HOH603 |
| A | HOH642 |
| A | HOH675 |
| A | HOH677 |
| A | HOH691 |
| A | HOH698 |
| C | PRO188 |
| A | ARG11 |
| A | ILE12 |
| A | ASN32 |
| A | ASP33 |
| A | ILE34 |
| A | MET35 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PGE A 402 |
| Chain | Residue |
| A | THR125 |
| A | PRO126 |
| A | THR127 |
| A | PHE128 |
| A | LEU216 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | SER20 |
| A | ARG23 |
| A | VAL26 |
| A | HOH732 |
| A | HOH753 |
| site_id | AC4 |
| Number of Residues | 36 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | ASN7 |
| B | GLY8 |
| B | GLY10 |
| B | ARG11 |
| B | ILE12 |
| B | ASN32 |
| B | ASP33 |
| B | ILE34 |
| B | MET35 |
| B | MET36 |
| B | ARG78 |
| B | SER96 |
| B | THR97 |
| B | GLY98 |
| B | ILE99 |
| B | SER120 |
| B | ALA121 |
| B | OCS149 |
| B | CSD149 |
| B | ALA180 |
| B | ASN314 |
| B | TYR318 |
| B | HOH519 |
| B | HOH523 |
| B | HOH531 |
| B | HOH561 |
| B | HOH584 |
| B | HOH611 |
| B | HOH624 |
| B | HOH626 |
| B | HOH628 |
| B | HOH629 |
| B | HOH640 |
| B | HOH644 |
| B | HOH673 |
| D | PRO188 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 402 |
| Chain | Residue |
| B | SER20 |
| B | ARG23 |
| B | VAL26 |
| B | HOH743 |
| B | HOH750 |
| site_id | AC6 |
| Number of Residues | 37 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | SER96 |
| C | THR97 |
| C | GLY98 |
| C | SER120 |
| C | ALA121 |
| C | OCS149 |
| C | CSD149 |
| C | ALA180 |
| C | ASN314 |
| C | TYR318 |
| C | HOH526 |
| C | HOH529 |
| C | HOH533 |
| C | HOH540 |
| C | HOH548 |
| C | HOH576 |
| C | HOH577 |
| C | HOH590 |
| C | HOH606 |
| C | HOH607 |
| C | HOH626 |
| C | HOH630 |
| C | HOH672 |
| C | HOH679 |
| C | HOH700 |
| A | PRO188 |
| C | ASN7 |
| C | GLY8 |
| C | GLY10 |
| C | ARG11 |
| C | ILE12 |
| C | ASN32 |
| C | ASP33 |
| C | ILE34 |
| C | MET35 |
| C | MET36 |
| C | ARG78 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 402 |
| Chain | Residue |
| C | SER20 |
| C | ARG23 |
| C | VAL26 |
| C | HOH724 |
| C | HOH727 |
| C | HOH743 |
| site_id | AC8 |
| Number of Residues | 34 |
| Details | binding site for residue NAD D 401 |
| Chain | Residue |
| D | ASN7 |
| D | GLY8 |
| D | GLY10 |
| D | ARG11 |
| D | ILE12 |
| D | ASN32 |
| D | ASP33 |
| D | ILE34 |
| D | MET35 |
| D | MET36 |
| D | ARG78 |
| D | SER96 |
| D | THR97 |
| D | GLY98 |
| D | ILE99 |
| D | SER120 |
| D | ALA121 |
| D | OCS149 |
| D | CSD149 |
| D | ALA180 |
| D | ASN314 |
| D | TYR318 |
| D | HOH538 |
| D | HOH541 |
| D | HOH548 |
| D | HOH551 |
| D | HOH571 |
| D | HOH577 |
| D | HOH603 |
| D | HOH607 |
| D | HOH645 |
| D | HOH655 |
| D | HOH659 |
| D | HOH673 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 402 |
| Chain | Residue |
| D | SER20 |
| D | ARG23 |
| D | VAL26 |
| D | HOH699 |
| D | HOH738 |
| D | HOH769 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| A | ALA147-LEU154 |
