5UQK
Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue U2F A 601 |
| Chain | Residue |
| A | VAL100 |
| A | TYR283 |
| A | ASP285 |
| A | VAL286 |
| A | ASP287 |
| A | ASN383 |
| A | GLN384 |
| A | THR464 |
| A | SER517 |
| A | MN602 |
| A | HOH710 |
| A | TRP101 |
| A | HOH722 |
| A | HOH899 |
| A | HOH909 |
| A | ILE102 |
| A | ASN138 |
| A | LEU264 |
| A | ALA265 |
| A | SER268 |
| A | ASP269 |
| A | ARG272 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | ASP287 |
| A | GLU514 |
| A | SER517 |
| A | U2F601 |
| A | HOH705 |
| A | HOH710 |
| A | HOH765 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:22747490, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:4DMV, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | VAL100 | |
| A | SER268 | |
| A | SER517 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | ASN138 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0007744|PDB:3SS1 |
| Chain | Residue | Details |
| A | ASP285 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:22747490, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:3SS1, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | ASP287 | |
| A | GLU514 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27571750, ECO:0007744|PDB:4R04 |
| Chain | Residue | Details |
| A | GLU544 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000305|PubMed:19553670 |
| Chain | Residue | Details |
| A | LEU542 |
