5UPU

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue IMP A 601

Chain	Residue
A	SER83
A	SER398
A	TYR421
A	GLY423
A	MET424
A	GLY425
A	GLU458
A	GLY459
A	6Q9602
A	MET85
A	SER339
A	ILE340
A	CYS341
A	ASP374
A	GLY375
A	GLY376
A	GLY397

---

site_id	AC2
Number of Residues	9
Details	binding site for residue 6Q9 A 602

Chain	Residue
A	ASP283
A	ALA285
A	GLY334
A	VAL335
A	GLY336
A	THR343
A	MET424
A	GLY425
A	IMP601

---

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGVGpGSICtT

Chain	Residue	Details
A	VAL331-THR343

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283

Chain	Residue	Details
A	CYS341

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283

Chain	Residue	Details
A	ARG443

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	ASP283
A	SER339
A	ASP374
A	GLY397
A	TYR421
A	GLU511
A	SER512
A	HIS513

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	ASN289
A	THR343
A	GLU458

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	GLY334

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	GLY336
A	GLY338
A	CYS341

---