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5UPF

Crystal structure of human NAMPT with isoindoline urea inhibitor compound 53

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD biosynthetic process
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD biosynthetic process
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
PDBデータベースに由来する情報
site_idAC1
残基数17
詳細binding site for residue 8HV A 901
鎖名残基
ATYR188
AARG311
AARG349
AILE351
AALA379
AHOH1027
AHOH1053
AHOH1123
BTYR18
ALYS189
AHIS191
APHE193
AARG196
AASP219
AALA244
ASER275
AILE309

site_idAC2
残基数17
詳細binding site for residue 8HV B 501
鎖名残基
ATYR18
AHOH1340
BTYR188
BLYS189
BHIS191
BPHE193
BARG196
BASP219
BALA244
BSER275
BARG311
BARG349
BILE351
BALA379
BHOH701
BHOH733
BHOH766

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数14
詳細BINDING:
鎖名残基詳細
AARG196
BHIS247
BARG311
BGLY353
BGLY384
BARG392
AASP219
AHIS247
AARG311
AGLY353
AGLY384
AARG392
BARG196
BASP219

site_idSWS_FT_FI2
残基数2
詳細MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
鎖名残基詳細
AMET1
BMET1

site_idSWS_FT_FI3
残基数2
詳細MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
鎖名残基詳細
ATYR188
BTYR188

site_idSWS_FT_FI4
残基数2
詳細MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
鎖名残基詳細
ASER472
BSER472

218853

件を2024-04-24に公開中

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