5UME
Crystal Structure of 5,10-Methylenetetrahydrofolate Reductase MetF from Haemophilus influenzae
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004489 | molecular_function | methylenetetrahydrofolate reductase (NAD(P)H) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006555 | biological_process | methionine metabolic process |
A | 0009086 | biological_process | methionine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
A | 0071949 | molecular_function | FAD binding |
A | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
B | 0004489 | molecular_function | methylenetetrahydrofolate reductase (NAD(P)H) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006555 | biological_process | methionine metabolic process |
B | 0009086 | biological_process | methionine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0035999 | biological_process | tetrahydrofolate interconversion |
B | 0071949 | molecular_function | FAD binding |
B | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
C | 0004489 | molecular_function | methylenetetrahydrofolate reductase (NAD(P)H) activity |
C | 0005829 | cellular_component | cytosol |
C | 0006555 | biological_process | methionine metabolic process |
C | 0009086 | biological_process | methionine biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0035999 | biological_process | tetrahydrofolate interconversion |
C | 0071949 | molecular_function | FAD binding |
C | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
D | 0004489 | molecular_function | methylenetetrahydrofolate reductase (NAD(P)H) activity |
D | 0005829 | cellular_component | cytosol |
D | 0006555 | biological_process | methionine metabolic process |
D | 0009086 | biological_process | methionine biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0035999 | biological_process | tetrahydrofolate interconversion |
D | 0071949 | molecular_function | FAD binding |
D | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
E | 0004489 | molecular_function | methylenetetrahydrofolate reductase (NAD(P)H) activity |
E | 0005829 | cellular_component | cytosol |
E | 0006555 | biological_process | methionine metabolic process |
E | 0009086 | biological_process | methionine biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0035999 | biological_process | tetrahydrofolate interconversion |
E | 0071949 | molecular_function | FAD binding |
E | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
F | 0004489 | molecular_function | methylenetetrahydrofolate reductase (NAD(P)H) activity |
F | 0005829 | cellular_component | cytosol |
F | 0006555 | biological_process | methionine metabolic process |
F | 0009086 | biological_process | methionine biosynthetic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0035999 | biological_process | tetrahydrofolate interconversion |
F | 0071949 | molecular_function | FAD binding |
F | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | binding site for residue FAD A 300 |
Chain | Residue |
A | THR57 |
A | ALA148 |
A | TYR150 |
A | HIS154 |
A | GLU156 |
A | ALA157 |
A | ASP163 |
A | ASN166 |
A | ARG169 |
A | LYS170 |
A | ILE179 |
A | TYR58 |
A | TYR273 |
A | ACY302 |
A | HOH405 |
A | HIS86 |
A | LEU115 |
A | ARG116 |
A | GLY117 |
A | ASP118 |
A | TYR129 |
A | ALA130 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 301 |
Chain | Residue |
A | ALA141 |
A | ASP142 |
A | HOH401 |
A | HOH407 |
C | ASP142 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue ACY A 302 |
Chain | Residue |
A | GLU26 |
A | TYR273 |
A | FAD300 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue EDO A 303 |
Chain | Residue |
A | TRP105 |
C | ARG138 |
site_id | AC5 |
Number of Residues | 22 |
Details | binding site for residue FAD B 300 |
Chain | Residue |
B | THR57 |
B | TYR58 |
B | HIS86 |
B | LEU115 |
B | ARG116 |
B | GLY117 |
B | ASP118 |
B | TYR129 |
B | ALA130 |
B | ALA148 |
B | TYR150 |
B | HIS154 |
B | GLU156 |
B | ALA157 |
B | ASP163 |
B | ASN166 |
B | ARG169 |
B | LYS170 |
B | TYR273 |
B | ACY302 |
B | HOH401 |
B | HOH402 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 301 |
Chain | Residue |
B | ASP142 |
B | ASP144 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ACY B 302 |
Chain | Residue |
B | GLU26 |
B | GLN181 |
B | TYR273 |
B | FAD300 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue FMT B 303 |
Chain | Residue |
B | SER24 |
B | LYS52 |
B | HIS177 |
B | VAL206 |
B | ASP269 |
site_id | AC9 |
Number of Residues | 24 |
Details | binding site for residue FAD C 300 |
Chain | Residue |
C | THR57 |
C | TYR58 |
C | ALA60 |
C | HIS86 |
C | THR88 |
C | LEU115 |
C | ARG116 |
C | GLY117 |
C | ASP118 |
C | TYR129 |
C | ALA130 |
C | ALA148 |
C | TYR150 |
C | HIS154 |
C | ALA157 |
C | ASP163 |
C | ASN166 |
C | ARG169 |
C | LYS170 |
C | ILE179 |
C | TYR273 |
C | ACY303 |
C | HOH403 |
C | HOH404 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue FMT C 301 |
Chain | Residue |
C | SER24 |
C | LYS52 |
C | HIS177 |
C | VAL206 |
C | ASP269 |
C | PHE270 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue FMT C 302 |
Chain | Residue |
C | GLU26 |
C | LEU275 |
C | HOH401 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ACY C 303 |
Chain | Residue |
C | GLN181 |
C | FAD300 |
C | HOH401 |
C | GLU26 |
site_id | AD4 |
Number of Residues | 23 |
Details | binding site for residue FAD D 300 |
Chain | Residue |
D | THR57 |
D | TYR58 |
D | HIS86 |
D | LEU115 |
D | ARG116 |
D | GLY117 |
D | ASP118 |
D | TYR129 |
D | ALA130 |
D | ALA148 |
D | TYR150 |
D | HIS154 |
D | GLU156 |
D | ALA157 |
D | ASP163 |
D | ASN166 |
D | ARG169 |
D | LYS170 |
D | ILE179 |
D | TYR273 |
D | ACY303 |
D | HOH404 |
D | HOH405 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue ACY D 301 |
Chain | Residue |
D | ASP142 |
D | ASP144 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue ACY D 302 |
Chain | Residue |
D | ARG102 |
D | ASP106 |
D | VAL140 |
E | LYS98 |
site_id | AD7 |
Number of Residues | 3 |
Details | binding site for residue ACY D 303 |
Chain | Residue |
D | GLU26 |
D | TYR273 |
D | FAD300 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue FMT D 304 |
Chain | Residue |
D | SER24 |
D | LYS52 |
D | HIS177 |
D | ASP269 |
site_id | AD9 |
Number of Residues | 25 |
Details | binding site for residue FAD E 300 |
Chain | Residue |
D | GLU95 |
E | THR57 |
E | TYR58 |
E | HIS86 |
E | THR88 |
E | LEU115 |
E | ARG116 |
E | GLY117 |
E | ASP118 |
E | TYR129 |
E | ALA130 |
E | ALA148 |
E | TYR150 |
E | HIS154 |
E | GLU156 |
E | ALA157 |
E | ASP163 |
E | ASN166 |
E | ARG169 |
E | LYS170 |
E | ILE179 |
E | TYR273 |
E | ACY301 |
E | HOH401 |
E | HOH407 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue ACY E 301 |
Chain | Residue |
E | GLU26 |
E | FAD300 |
site_id | AE2 |
Number of Residues | 26 |
Details | binding site for residue FAD F 300 |
Chain | Residue |
F | THR57 |
F | TYR58 |
F | ALA60 |
F | HIS86 |
F | THR88 |
F | LEU115 |
F | ARG116 |
F | GLY117 |
F | ASP118 |
F | TYR129 |
F | ALA130 |
F | ALA148 |
F | TYR150 |
F | HIS154 |
F | GLU156 |
F | ALA157 |
F | ASP163 |
F | ASN166 |
F | ARG169 |
F | LYS170 |
F | ILE179 |
F | TYR273 |
F | ACY301 |
F | HOH402 |
F | HOH405 |
F | HOH407 |
site_id | AE3 |
Number of Residues | 3 |
Details | binding site for residue ACY F 301 |
Chain | Residue |
F | GLU26 |
F | TYR273 |
F | FAD300 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue ACY F 302 |
Chain | Residue |
F | ARG138 |
F | ASP142 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue EDO F 303 |
Chain | Residue |
F | ASN22 |
F | SER24 |
F | LYS52 |
F | PHE53 |
F | HIS177 |
F | ASP269 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P0AEZ1 |
Chain | Residue | Details |
A | GLU26 | |
B | GLU26 | |
C | GLU26 | |
D | GLU26 | |
E | GLU26 | |
F | GLU26 |
site_id | SWS_FT_FI2 |
Number of Residues | 108 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0AEZ1 |
Chain | Residue | Details |
A | THR57 | |
A | HIS154 | |
F | HIS154 | |
F | ALA157 | |
F | ASP163 | |
F | ASN166 | |
F | ARG169 | |
F | LYS170 | |
F | GLN181 | |
F | GLN217 | |
F | ARG277 | |
A | ALA157 | |
A | ASP163 | |
A | ASN166 | |
A | ARG169 | |
A | LYS170 | |
A | GLN181 | |
A | GLN217 | |
A | ARG277 | |
B | THR57 | |
A | TYR58 | |
B | TYR58 | |
B | ALA60 | |
B | HIS86 | |
B | ARG116 | |
B | GLY117 | |
B | ASP118 | |
B | ALA130 | |
B | TYR150 | |
B | HIS154 | |
B | ALA157 | |
A | ALA60 | |
B | ASP163 | |
B | ASN166 | |
B | ARG169 | |
B | LYS170 | |
B | GLN181 | |
B | GLN217 | |
B | ARG277 | |
C | THR57 | |
C | TYR58 | |
C | ALA60 | |
A | HIS86 | |
C | HIS86 | |
C | ARG116 | |
C | GLY117 | |
C | ASP118 | |
C | ALA130 | |
C | TYR150 | |
C | HIS154 | |
C | ALA157 | |
C | ASP163 | |
C | ASN166 | |
A | ARG116 | |
C | ARG169 | |
C | LYS170 | |
C | GLN181 | |
C | GLN217 | |
C | ARG277 | |
D | THR57 | |
D | TYR58 | |
D | ALA60 | |
D | HIS86 | |
D | ARG116 | |
A | GLY117 | |
D | GLY117 | |
D | ASP118 | |
D | ALA130 | |
D | TYR150 | |
D | HIS154 | |
D | ALA157 | |
D | ASP163 | |
D | ASN166 | |
D | ARG169 | |
D | LYS170 | |
A | ASP118 | |
D | GLN181 | |
D | GLN217 | |
D | ARG277 | |
E | THR57 | |
E | TYR58 | |
E | ALA60 | |
E | HIS86 | |
E | ARG116 | |
E | GLY117 | |
E | ASP118 | |
A | ALA130 | |
E | ALA130 | |
E | TYR150 | |
E | HIS154 | |
E | ALA157 | |
E | ASP163 | |
E | ASN166 | |
E | ARG169 | |
E | LYS170 | |
E | GLN181 | |
E | GLN217 | |
A | TYR150 | |
E | ARG277 | |
F | THR57 | |
F | TYR58 | |
F | ALA60 | |
F | HIS86 | |
F | ARG116 | |
F | GLY117 | |
F | ASP118 | |
F | ALA130 | |
F | TYR150 |