5ULW

Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue TTP A 501

Chain	Residue
A	ASP34
A	ARG71
A	LYS77
A	ASP126
A	LYS214
A	MG502
A	HOH612
A	HOH627
A	HOH637
P	DOC873
T	MA7840
A	LEU35
T	DG841
A	ASP36
A	CYS37
A	PHE38
A	TYR39
A	VAL64
A	THR65
A	TYR68

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site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 502

Chain	Residue
A	ASP34
A	LEU35
A	ASP126
A	TTP501

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site_id	AC3
Number of Residues	1
Details	binding site for residue CL A 503

Chain	Residue
A	ASN290

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216

Chain	Residue	Details
A	GLU127

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5

Chain	Residue	Details
A	ASP34
A	LEU35
A	ASP126

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N

Chain	Residue	Details
A	TYR39
A	ARG71

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