5UL4
Structure of Cobalamin-dependent S-adenosylmethionine radical enzyme OxsB with aqua-cobalamin and S-adenosylmethionine bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 A 801 |
| Chain | Residue |
| A | CYS313 |
| A | SER316 |
| A | CYS318 |
| A | CYS321 |
| A | ARG399 |
| A | SAM803 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | binding site for residue B12 A 802 |
| Chain | Residue |
| A | GLY182 |
| A | LEU183 |
| A | SER184 |
| A | PHE187 |
| A | GLY216 |
| A | ASN217 |
| A | CYS237 |
| A | LYS239 |
| A | GLU240 |
| A | GLY241 |
| A | GLU242 |
| A | GLU308 |
| A | ARG311 |
| A | CYS321 |
| A | PRO322 |
| A | HIS325 |
| A | LYS326 |
| A | ALA361 |
| A | GLU363 |
| A | SAM803 |
| A | EDO819 |
| A | HOH912 |
| A | HOH974 |
| A | HOH1008 |
| A | HOH1017 |
| A | HOH1053 |
| A | HOH1065 |
| A | HOH1084 |
| A | HOH1101 |
| A | HOH1146 |
| A | HOH1178 |
| A | HOH1269 |
| A | HOH1306 |
| A | PHE131 |
| A | ARG135 |
| A | SER139 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | binding site for residue SAM A 803 |
| Chain | Residue |
| A | PHE320 |
| A | GLU363 |
| A | ALA397 |
| A | ALA398 |
| A | ARG399 |
| A | PHE432 |
| A | GLY434 |
| A | GLU436 |
| A | LYS448 |
| A | GLY472 |
| A | PHE473 |
| A | ILE474 |
| A | SER543 |
| A | MET544 |
| A | GLU545 |
| A | SF4801 |
| A | B12802 |
| A | HOH906 |
| A | HOH912 |
| A | HOH924 |
| A | HOH952 |
| A | HOH986 |
| A | HOH1033 |
| A | HOH1082 |
| A | HOH1101 |
| A | HOH1241 |
| A | HOH1379 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue MES A 804 |
| Chain | Residue |
| A | TRP88 |
| A | HIS89 |
| A | SER107 |
| A | CYS108 |
| A | ASP314 |
| A | ARG317 |
| A | GLU368 |
| A | LEU369 |
| A | PRO370 |
| A | EDO806 |
| A | HOH905 |
| A | HOH1035 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 805 |
| Chain | Residue |
| A | LEU14 |
| A | LYS18 |
| A | PRO75 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 806 |
| Chain | Residue |
| A | TRP92 |
| A | MES804 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 807 |
| Chain | Residue |
| A | THR280 |
| A | LEU327 |
| A | ARG328 |
| A | SER329 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 808 |
| Chain | Residue |
| A | TYR627 |
| A | MET630 |
| A | ARG634 |
| A | HOH963 |
| A | HOH1048 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 809 |
| Chain | Residue |
| A | ARG430 |
| A | LEU469 |
| A | ARG470 |
| A | HOH1012 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 810 |
| Chain | Residue |
| A | ASN468 |
| A | LEU469 |
| A | HOH994 |
| A | HOH1003 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 811 |
| Chain | Residue |
| A | GLU285 |
| A | SER334 |
| A | GLN337 |
| A | HOH1051 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 812 |
| Chain | Residue |
| A | SER538 |
| A | TYR539 |
| A | MET540 |
| A | ARG634 |
| A | HOH930 |
| A | HOH943 |
| A | HOH1107 |
| A | HOH1120 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 813 |
| Chain | Residue |
| A | HIS351 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 814 |
| Chain | Residue |
| A | LEU493 |
| A | TYR534 |
| A | MET540 |
| A | LEU541 |
| A | HIS638 |
| A | HOH981 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 815 |
| Chain | Residue |
| A | GLU116 |
| A | LYS625 |
| A | SER628 |
| A | HOH971 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 816 |
| Chain | Residue |
| A | ARG135 |
| A | TYR359 |
| A | HOH907 |
| A | HOH1089 |
| A | HOH1100 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 817 |
| Chain | Residue |
| A | LYS393 |
| A | ALA424 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 818 |
| Chain | Residue |
| A | HIS114 |
| A | LYS253 |
| A | GLU255 |
| A | HOH1169 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 819 |
| Chain | Residue |
| A | TYR539 |
| A | B12802 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 140 |
| Details | Domain: {"description":"B12-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00666","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 246 |
| Details | Domain: {"description":"Radical SAM core","evidences":[{"source":"PROSITE-ProRule","id":"PRU01266","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28346939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UL3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UL4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28346939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UL4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
