5UL4

Structure of Cobalamin-dependent S-adenosylmethionine radical enzyme OxsB with aqua-cobalamin and S-adenosylmethionine bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0031419	molecular_function	cobalamin binding
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SF4 A 801

Chain	Residue
A	CYS313
A	SER316
A	CYS318
A	CYS321
A	ARG399
A	SAM803

---

site_id	AC2
Number of Residues	36
Details	binding site for residue B12 A 802

Chain	Residue
A	GLY182
A	LEU183
A	SER184
A	PHE187
A	GLY216
A	ASN217
A	CYS237
A	LYS239
A	GLU240
A	GLY241
A	GLU242
A	GLU308
A	ARG311
A	CYS321
A	PRO322
A	HIS325
A	LYS326
A	ALA361
A	GLU363
A	SAM803
A	EDO819
A	HOH912
A	HOH974
A	HOH1008
A	HOH1017
A	HOH1053
A	HOH1065
A	HOH1084
A	HOH1101
A	HOH1146
A	HOH1178
A	HOH1269
A	HOH1306
A	PHE131
A	ARG135
A	SER139

---

site_id	AC3
Number of Residues	27
Details	binding site for residue SAM A 803

Chain	Residue
A	PHE320
A	GLU363
A	ALA397
A	ALA398
A	ARG399
A	PHE432
A	GLY434
A	GLU436
A	LYS448
A	GLY472
A	PHE473
A	ILE474
A	SER543
A	MET544
A	GLU545
A	SF4801
A	B12802
A	HOH906
A	HOH912
A	HOH924
A	HOH952
A	HOH986
A	HOH1033
A	HOH1082
A	HOH1101
A	HOH1241
A	HOH1379

---

site_id	AC4
Number of Residues	12
Details	binding site for residue MES A 804

Chain	Residue
A	TRP88
A	HIS89
A	SER107
A	CYS108
A	ASP314
A	ARG317
A	GLU368
A	LEU369
A	PRO370
A	EDO806
A	HOH905
A	HOH1035

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 805

Chain	Residue
A	LEU14
A	LYS18
A	PRO75

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 806

Chain	Residue
A	TRP92
A	MES804

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 807

Chain	Residue
A	THR280
A	LEU327
A	ARG328
A	SER329

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 808

Chain	Residue
A	TYR627
A	MET630
A	ARG634
A	HOH963
A	HOH1048

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 809

Chain	Residue
A	ARG430
A	LEU469
A	ARG470
A	HOH1012

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 810

Chain	Residue
A	ASN468
A	LEU469
A	HOH994
A	HOH1003

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO A 811

Chain	Residue
A	GLU285
A	SER334
A	GLN337
A	HOH1051

---

site_id	AD3
Number of Residues	8
Details	binding site for residue EDO A 812

Chain	Residue
A	SER538
A	TYR539
A	MET540
A	ARG634
A	HOH930
A	HOH943
A	HOH1107
A	HOH1120

---

site_id	AD4
Number of Residues	1
Details	binding site for residue EDO A 813

Chain	Residue
A	HIS351

---

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO A 814

Chain	Residue
A	LEU493
A	TYR534
A	MET540
A	LEU541
A	HIS638
A	HOH981

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 815

Chain	Residue
A	GLU116
A	LYS625
A	SER628
A	HOH971

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO A 816

Chain	Residue
A	ARG135
A	TYR359
A	HOH907
A	HOH1089
A	HOH1100

---

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO A 817

Chain	Residue
A	LYS393
A	ALA424

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 818

Chain	Residue
A	HIS114
A	LYS253
A	GLU255
A	HOH1169

---

site_id	AE1
Number of Residues	2
Details	binding site for residue EDO A 819

Chain	Residue
A	TYR539
A	B12802

---