5UL3

Structure of Cobalamin-dependent S-adenosylmethionine radical enzyme OxsB with aqua-cobalamin bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016853	molecular_function	isomerase activity
A	0031419	molecular_function	cobalamin binding
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SF4 A 801

Chain	Residue
A	CYS313
A	SER316
A	CYS318
A	CYS321
A	ARG399
A	DTT803

---

site_id	AC2
Number of Residues	42
Details	binding site for residue B12 A 802

Chain	Residue
A	GLN161
A	GLY182
A	LEU183
A	SER184
A	PHE187
A	GLY216
A	ASN217
A	CYS237
A	LYS239
A	GLU240
A	GLY241
A	GLU242
A	GLU308
A	ARG311
A	CYS321
A	PRO322
A	HIS325
A	LYS326
A	ALA361
A	GLU363
A	GLU545
A	DTT803
A	EDO821
A	HOH904
A	HOH924
A	HOH987
A	HOH1001
A	HOH1009
A	HOH1032
A	HOH1036
A	HOH1064
A	HOH1088
A	HOH1142
A	HOH1226
A	HOH1267
A	HOH1326
A	HOH1331
A	HOH1396
A	HOH1420
A	PHE131
A	ARG135
A	SER139

---

site_id	AC3
Number of Residues	7
Details	binding site for residue DTT A 803

Chain	Residue
A	GLU363
A	ALA397
A	SF4801
A	B12802
A	HOH1031
A	HOH1064
A	HOH1126

---

site_id	AC4
Number of Residues	10
Details	binding site for residue MES A 804

Chain	Residue
A	TRP88
A	HIS89
A	SER107
A	CYS108
A	ASP314
A	ARG317
A	GLU368
A	PRO370
A	HOH914
A	HOH1321

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 805

Chain	Residue
A	ASN468
A	LEU469
A	HOH948
A	HOH1181

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 806

Chain	Residue
A	LEU469
A	ARG470
A	VAL537
A	HOH942
A	HOH969

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 807

Chain	Residue
A	MET475
A	LEU493
A	TYR534
A	MET540
A	LEU541
A	HIS638
A	HOH1055

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 808

Chain	Residue
A	TYR539
A	MET540
A	ILE601
A	EDO828
A	HOH1078
A	HOH1191

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 809

Chain	Residue
A	VAL617
A	THR714
A	ASP715
A	HOH1034

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 810

Chain	Residue
A	ASP703
A	ALA706
A	ASP707
A	LYS710

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 811

Chain	Residue
A	HOH922
A	HOH1204
A	LYS257
A	LEU258
A	ASP259
A	GLU269

---

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO A 812

Chain	Residue
A	ASP259
A	ASN276
A	HOH1253

---

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO A 813

Chain	Residue
A	GLU150
A	HOH1344

---

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO A 814

Chain	Residue
A	PRO75
A	HOH1063

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 815

Chain	Residue
A	THR373
A	GLN376
A	ARG377
A	ASP380

---

site_id	AD7
Number of Residues	7
Details	binding site for residue EDO A 816

Chain	Residue
A	SER6
A	SER9
A	GLU44
A	LYS588
A	THR589
A	GLY681
A	HOH1358

---

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO A 817

Chain	Residue
A	MET251
A	ASN619

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 818

Chain	Residue
A	LEU327
A	ARG328
A	SER329
A	HOH932

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO A 819

Chain	Residue
A	TYR627
A	ARG634
A	HOH1046
A	HOH1163

---

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO A 820

Chain	Residue
A	TYR201
A	ARG230
A	TYR231
A	PRO232
A	SER233

---

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO A 821

Chain	Residue
A	ARG135
A	TYR359
A	B12802
A	HOH1058
A	HOH1170

---

site_id	AE4
Number of Residues	5
Details	binding site for residue EDO A 822

Chain	Residue
A	ILE24
A	ASP344
A	ARG347
A	HOH901
A	HOH1167

---

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO A 823

Chain	Residue
A	PHE432
A	GLU436
A	GLY472
A	HOH1126

---

site_id	AE6
Number of Residues	4
Details	binding site for residue EDO A 824

Chain	Residue
A	GLU545
A	HOH924
A	HOH1061
A	HOH1382

---

site_id	AE7
Number of Residues	6
Details	binding site for residue EDO A 825

Chain	Residue
A	GLU94
A	ILE95
A	GLU96
A	LYS239
A	ASP324
A	EDO826

---

site_id	AE8
Number of Residues	6
Details	binding site for residue EDO A 826

Chain	Residue
A	SER221
A	PHE222
A	ASP238
A	ASP324
A	EDO825
A	HOH977

---

site_id	AE9
Number of Residues	4
Details	binding site for residue EDO A 827

Chain	Residue
A	HIS665
A	LYS699
A	LEU700
A	ASP703

---

site_id	AF1
Number of Residues	6
Details	binding site for residue EDO A 828

Chain	Residue
A	SER538
A	MET540
A	ARG634
A	EDO808
A	HOH1078
A	HOH1176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"B12-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00666","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	246
Details	Domain: {"description":"Radical SAM core","evidences":[{"source":"PROSITE-ProRule","id":"PRU01266","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28346939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UL3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28346939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---