5UKI
Mn2+ and Zn2+ requirements for the lariat debranching enzyme, Dbr1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008419 | molecular_function | RNA lariat debranching enzyme activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 400 |
| Chain | Residue |
| A | CYS14 |
| A | HIS16 |
| A | ASP45 |
| A | HIS232 |
| A | MN401 |
| A | HOH545 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 401 |
| Chain | Residue |
| A | HIS230 |
| A | ZN400 |
| A | HOH545 |
| A | ASP45 |
| A | ASN90 |
| A | HIS180 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27930312, ECO:0000269|PubMed:28504306, ECO:0007744|PDB:5K73, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78, ECO:0007744|PDB:5UKI |
| Chain | Residue | Details |
| A | CYS14 | |
| A | HIS16 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|PubMed:27930312, ECO:0000269|PubMed:28504306, ECO:0007744|PDB:4PEF, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEH, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:5K73, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78, ECO:0007744|PDB:5UKI |
| Chain | Residue | Details |
| A | ASP45 | |
| A | HIS180 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|Ref.6, ECO:0007744|PDB:4PEH, ECO:0007744|PDB:8DZK |
| Chain | Residue | Details |
| A | LYS59 | |
| A | LYS134 | |
| A | HIS156 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|Ref.6, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:8DZK |
| Chain | Residue | Details |
| A | ASN90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI |
| Chain | Residue | Details |
| A | HIS91 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|PubMed:27930312, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78 |
| Chain | Residue | Details |
| A | GLY201 | |
| A | HIS232 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|PubMed:27930312, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEH, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78 |
| Chain | Residue | Details |
| A | ASP205 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27930312, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI |
| Chain | Residue | Details |
| A | HIS230 | |
| A | MET231 |
