5UJY

The structure of Mycobacterium tuberculosis topoisomerase I from the 2nd crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003916	molecular_function	DNA topoisomerase activity
B	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
B	0006265	biological_process	DNA topological change

Functional Information from PROSITE/UniProt

site_id	PS00396
Number of Residues	15
Details	TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. QrLYEngy.........ITYmRTD

Chain	Residue	Details
A	GLN332-ASP346

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01383

Chain	Residue	Details
A	TYR342
B	TYR342

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00952

Chain	Residue	Details
B	GLU24
B	ASP111
A	ASP111
A	GLU24

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site_id	SWS_FT_FI3
Number of Residues	16
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_00952

Chain	Residue	Details
A	TYR176
A	TRP183
A	ARG344
A	ARG547
B	HIS48
B	ARG167
B	ARG168
B	ASP171
B	TYR176
B	TRP183
B	ARG344
B	ARG547
A	HIS48
A	ARG167
A	ARG168
A	ASP171

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