5UJM

Structure of the active form of human Origin Recognition Complex and its ATPase motor module

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0000808	cellular_component	origin recognition complex
B	0005634	cellular_component	nucleus
B	0006260	biological_process	DNA replication
C	0003677	molecular_function	DNA binding
C	0005664	cellular_component	nuclear origin of replication recognition complex
C	0006260	biological_process	DNA replication
D	0000166	molecular_function	nucleotide binding
D	0000781	cellular_component	chromosome, telomeric region
D	0000808	cellular_component	origin recognition complex
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005664	cellular_component	nuclear origin of replication recognition complex
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0016887	molecular_function	ATP hydrolysis activity
D	0040038	biological_process	polar body extrusion after meiotic divisions
D	0051258	biological_process	protein polymerization
E	0000166	molecular_function	nucleotide binding
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000808	cellular_component	origin recognition complex
E	0003674	molecular_function	molecular_function
E	0003688	molecular_function	DNA replication origin binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005664	cellular_component	nuclear origin of replication recognition complex
E	0005694	cellular_component	chromosome
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006275	biological_process	regulation of DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ATP A 901

Chain	Residue
A	VAL500
A	ASN654
A	TYR681
A	ILE689
A	ALA719
A	ARG720
A	LEU723
A	MG902
D	ARG209
A	GLU502
A	CYS506
A	PRO536
A	GLY539
A	LYS540
A	THR541
A	ALA542
A	GLU621

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site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 902

Chain	Residue
A	THR541
A	ASP620
A	GLU621
A	ATP901

---

site_id	AC3
Number of Residues	17
Details	binding site for residue ATP D 901

Chain	Residue
D	GLN31
D	ASN36
D	PHE38
D	VAL40
D	PRO68
D	ARG69
D	GLY70
D	SER71
D	GLY72
D	LYS73
D	THR74
D	MET75
D	LEU276
D	ARG277
D	HIS280
D	MG902
E	ARG143

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG D 902

Chain	Residue
D	THR74
D	ASP159
D	ATP901
E	ARG143

---

site_id	AC5
Number of Residues	15
Details	binding site for residue ATP E 501

Chain	Residue
E	LEU9
E	HIS38
E	THR39
E	ALA40
E	SER41
E	GLY42
E	LYS43
E	THR44
E	TYR45
E	ASP125
E	GLU159
E	TYR182
E	ILE190
E	LEU222
E	ARG226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
E	GLY37
A	ASN654
A	ARG720

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
D	LYS7
A	ASP620
A	GLU621

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER478

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