5UJK

Malate dehydrogenase from Methylobacterium extorquens, complexed with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0006089	biological_process	lactate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0030060	molecular_function	L-malate dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue NAD A 401

Chain	Residue
A	GLY12
A	GLY80
A	VAL99
A	ILE119
A	ASN121
A	MET144
A	LEU148
A	HIS176
A	HOH512
A	HOH517
A	HOH522
A	GLN13
A	HOH528
A	HOH546
A	HOH549
A	HOH559
A	HOH579
A	HOH580
A	HOH595
A	HOH635
A	HOH642
A	HOH658
A	ILE14
A	HOH712
A	HOH726
A	PHE33
A	ASP34
A	ILE35
A	VAL36
A	THR78
A	ALA79

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site_id	AC2
Number of Residues	7
Details	binding site for residue CA A 402

Chain	Residue
A	GLU287
A	GLU287
A	HOH612
A	HOH614
A	HOH673
A	HOH705
A	HOH714

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site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 403

Chain	Residue
A	GLU166
A	HOH510
A	HOH607
A	HOH646
A	HOH663
A	HOH728

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site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 404

Chain	Residue
A	ARG154
A	ARG252
A	HOH574
A	HOH727

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00487

Chain	Residue	Details
A	HIS176

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00487

Chain	Residue	Details
A	ASP34
A	ARG83
A	ARG89
A	ASN96
A	ILE119
A	ASN121
A	ARG152
A	GLY10

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