5UJ2

Crystal structure of HCV NS5B genotype 2A JFH-1 isolate with S15G E86Q E87Q C223H V321I mutations and Delta8 neta hairpoin loop deletion in complex with GS-639476 (diphsohate version of GS-9813), Mn2+ and symmetrical primer template 5'-AUAAAUUU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MN P 601

Chain	Residue
A	ASP220
A	ASP318
A	ASP319
A	MN601
P	U8
P	8B4602
P	HOH702

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site_id	AC2
Number of Residues	16
Details	binding site for residue 8B4 P 602

Chain	Residue
A	THR221
A	HIS223
A	PHE224
A	ASP225
A	SER282
A	ASN291
A	ASP318
A	MN601
P	U8
P	MN601
P	HOH701
P	HOH702
T	U2
T	A3
A	ARG158
A	ASP220

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site_id	AC3
Number of Residues	6
Details	binding site for residue MN A 601

Chain	Residue
A	ASP220
A	THR221
A	ASP318
P	MN601
P	8B4602
P	HOH701

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site_id	AC4
Number of Residues	2
Details	binding site for residue MN A 602

Chain	Residue
A	GLU237
A	HIS254

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site_id	AC5
Number of Residues	5
Details	binding site for residue CL A 603

Chain	Residue
A	GLY375
A	PRO376
A	ARG377
A	GLY378
A	ARG379

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P26663

Chain	Residue	Details
A	ASP220
A	ASP318
A	ASP319

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