5UJ1

Crystal structure of Mycobacterium tuberculosis Topoisomerase I at 2.15A resolution limit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 801

Chain	Residue
A	ARG54
A	ARG168
A	ARG172
A	HOH901
A	HOH1097

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Functional Information from PROSITE/UniProt

site_id	PS00396
Number of Residues	15
Details	TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. QrLYEngy.........ITYmRTD

Chain	Residue	Details
A	GLN332-ASP346

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01383

Chain	Residue	Details
A	TYR342

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00952

Chain	Residue	Details
A	GLU24
A	ASP111

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site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_00952

Chain	Residue	Details
A	HIS48
A	ARG167
A	ARG168
A	ASP171
A	TYR176
A	TRP183
A	ARG344
A	ARG547

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