5UIU
Crystal structure of IRAK4 in complex with compound 30
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007165 | biological_process | signal transduction |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007165 | biological_process | signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 8CG A 4000 |
| Chain | Residue |
| A | MET192 |
| A | TYR264 |
| A | MET265 |
| A | GLY268 |
| A | ALA315 |
| A | ASN316 |
| A | LEU318 |
| A | SER328 |
| A | ASP329 |
| A | HOH4129 |
| A | HOH4149 |
| A | GLU194 |
| A | GLY195 |
| A | GLY198 |
| A | VAL200 |
| A | ALA211 |
| A | LYS213 |
| A | TYR262 |
| A | VAL263 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue 8CG B 4000 |
| Chain | Residue |
| B | MET192 |
| B | GLU194 |
| B | GLY195 |
| B | GLY198 |
| B | VAL200 |
| B | ALA211 |
| B | LYS213 |
| B | TYR262 |
| B | VAL263 |
| B | TYR264 |
| B | MET265 |
| B | GLY268 |
| B | ALA315 |
| B | ASN316 |
| B | LEU318 |
| B | SER328 |
| B | ASP329 |
| B | HOH4113 |
| B | HOH4175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ASP311 | |
| B | ASP311 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | MET192 | |
| B | MET192 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS213 | |
| A | LYS313 | |
| A | ASP329 | |
| B | LYS213 | |
| B | LYS313 | |
| B | ASP329 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32 |
| Chain | Residue | Details |
| A | TPO342 | |
| B | TPO342 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32 |
| Chain | Residue | Details |
| A | TPO345 | |
| B | TPO345 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103 |
| Chain | Residue | Details |
| A | SEP346 | |
| B | SEP346 |
