5UG4
Structure of spermidine N-acetyltransferase SpeG from Vibrio cholerae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006598 | biological_process | polyamine catabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0046203 | biological_process | spermidine catabolic process |
| A | 0046208 | biological_process | spermine catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006598 | biological_process | polyamine catabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0046203 | biological_process | spermidine catabolic process |
| B | 0046208 | biological_process | spermine catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006598 | biological_process | polyamine catabolic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0046203 | biological_process | spermidine catabolic process |
| C | 0046208 | biological_process | spermine catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 201 |
| Chain | Residue |
| A | GLU33 |
| A | GLU75 |
| A | HOH362 |
| C | GLU75 |
| C | CA201 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 202 |
| Chain | Residue |
| B | HOH329 |
| B | HOH361 |
| A | GLU34 |
| A | PRO35 |
| A | GLU41 |
| B | ASN53 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 203 |
| Chain | Residue |
| A | ASN22 |
| A | HOH306 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MRD A 204 |
| Chain | Residue |
| A | HIS122 |
| A | VAL123 |
| A | ALA124 |
| A | HOH376 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 201 |
| Chain | Residue |
| B | GLU33 |
| B | GLU33 |
| B | GLU75 |
| B | GLU75 |
| B | HOH302 |
| B | HOH302 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 202 |
| Chain | Residue |
| B | GLU33 |
| B | GLU75 |
| B | GLU75 |
| B | CA203 |
| B | HOH364 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 203 |
| Chain | Residue |
| B | GLU33 |
| B | GLU75 |
| B | GLU75 |
| B | CA202 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 204 |
| Chain | Residue |
| B | GLU34 |
| B | PRO35 |
| B | GLU41 |
| C | ASN53 |
| C | HOH304 |
| C | HOH328 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue ACT B 205 |
| Chain | Residue |
| B | ILE151 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue EOH B 206 |
| Chain | Residue |
| B | ASN53 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue CA C 201 |
| Chain | Residue |
| A | GLU33 |
| A | GLU75 |
| A | CA201 |
| A | HOH344 |
| C | GLU33 |
| C | GLU75 |
| C | CA202 |
| C | HOH306 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 202 |
| Chain | Residue |
| A | GLU75 |
| A | HOH316 |
| C | GLU33 |
| C | GLU75 |
| C | CA201 |
| C | HOH346 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 203 |
| Chain | Residue |
| A | ASN53 |
| A | HOH317 |
| A | HOH364 |
| C | GLU34 |
| C | PRO35 |
| C | GLU41 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue ACT C 204 |
| Chain | Residue |
| C | ILE151 |
| C | HOH353 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P0A951 |
| Chain | Residue | Details |
| A | TYR134 | |
| B | TYR134 | |
| C | TYR134 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0000269|Ref.3, ECO:0007744|PDB:4MJ8 |
| Chain | Residue | Details |
| A | MET28 | |
| A | GLU84 | |
| B | MET28 | |
| B | GLU84 | |
| C | MET28 | |
| C | GLU84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4MI4 |
| Chain | Residue | Details |
| A | GLU33 | |
| B | GLU33 | |
| C | GLU33 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4MI4, ECO:0007744|PDB:4R87 |
| Chain | Residue | Details |
| A | GLU41 | |
| B | GLU41 | |
| C | GLU41 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4R87 |
| Chain | Residue | Details |
| A | HIS49 | |
| B | HIS49 | |
| C | HIS49 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0000269|PubMed:26410587, ECO:0007744|PDB:5CNP |
| Chain | Residue | Details |
| A | GLU75 | |
| B | GLU75 | |
| C | GLU75 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4R57, ECO:0007744|PDB:4R87 |
| Chain | Residue | Details |
| A | ILE87 | |
| A | GLN94 | |
| B | ILE87 | |
| B | GLN94 | |
| C | ILE87 | |
| C | GLN94 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4R57 |
| Chain | Residue | Details |
| A | ASN127 | |
| B | ASN127 | |
| C | ASN127 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | SITE: Could be important for selectivity toward long polyamines => ECO:0000305|PubMed:25623305 |
| Chain | Residue | Details |
| A | GLU84 | |
| B | GLU84 | |
| C | GLU84 |
