5UG3
NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID MUTANT A10V
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS60014 |
| Number of Residues | 15 |
| Details | ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSnPVCRvnnpHVC |
| Chain | Residue | Details |
| A | CYS5-CYS19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Region: {"description":"N-terminal tail important for activity on alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR","evidences":[{"source":"PubMed","id":"12419800","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19098004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24122487","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Region: {"description":"Ser-Xaa-Pro motif, crucial for potent interaction with nAChR","evidences":[{"source":"UniProtKB","id":"P56636","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for activity on alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR","evidences":[{"source":"PubMed","id":"19098004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24122487","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for activity on alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR","evidences":[{"source":"PubMed","id":"19098004","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for determining subtype selectivity","evidences":[{"source":"PubMed","id":"24122487","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for activity on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR","evidences":[{"source":"PubMed","id":"12419800","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19098004","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for activity on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR","evidences":[{"source":"PubMed","id":"19098004","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"PubMed","id":"12419800","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"PubMed","id":"12419800","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
